A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

Conditions

• MTAP-deleted Solid Tumors

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• BAY 3713372 — DRUG
  Daily oral administration

Study Details

The study treatment, BAY 3713372, is under development to treat MTAP (methylthioadenosine phosphorylase)-deleted solid tumors. It is thought to work by blocking the protein arginine N-methyltransferase 5 (PRMT5). This may kill the MTAP-deleted cancer cells while sparing the normal cells. The main objective of this first-in-human study is to learn how safe BAY 3713372 is, how the body processes it, and how well it works in people with MTAP-deleted solid tumors. For this, the researchers will study and analyze: * the number of participants who have adverse events (AEs) after receiving different doses of BAY 3713372 and the AE's severity. * the number of participants who experience dose-limiting toxicities (DLTs) after receiving different doses of BAY 3713372, the DLT's severity and how often they happened. A DLT is a pre-defined medical problem caused by a specific dose of a drug that is too severe to continue using that dose. * the total amount of BAY 3713372 in participants' blood (also called AUC) over time after single and multiple doses. * the highest level of BAY 3713372 in participants' blood (also called Cmax) after single and multiple doses. Other than the main objective, researchers will also check for the number of participants who show a response to treatment and how long they live without the cancer getting worse. The study participants will take part in one of the eight distinct groups or "intervention cohorts" of the study. The study will start with a dose escalation phase where distinct groups of participants will receive different doses of BAY 3713372 alone to find the dose that is deemed safe and works best for the participants. When this dose has been found, a larger number of participants will receive BAY 3713372 alone or with other treatments in a dose expansion phase. Participants may take the study treatment as long as they benefit from the treatment without any severe medical problems. Participants will visit the study site: * at least twice before the treatment starts * multiple times when they start taking the treatment * once after 30 days of receiving the last dose and every 9 weeks after that until the cancer worsens, or the participant stops for any other reason During the study, the doctors and their study team will: * check participants' health by performing tests such as blood and urine tests, and checking heart health using an electrocardiogram * check if the participants' cancer has grown and/or spread using computed tomography (CT) or magnetic resonance imaging (MRI) and, if needed, bone scan * take tumor samples The study doctors and their team will contact the participants every 3 months until 2 years after the last participant's last dose or the end of the study to learn about the participant's health.

Key Dates

Start date

Mar 21, 2025

Status verified

Jun 2026

Primary completion

Jun 17, 2029

Completion

Jun 17, 2029

Study Design

Enrollment

450 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Arms

• Experimental: Dose Escalation (Intervention Cohort 1)
  For the escalation part, different dose levels of BAY 3713372 administered as monotherapy are planned.
• Experimental: Backfill cohorts in Intervention Cohort 1 (Dose Escalation)
  Backfill cohorts may be initiated concurrently with dose escalation cohorts to generate additional safety, pharmacokinetic, and pharmacodynamic data to facilitate the selection of the optimal doses for use in further development.
• Experimental: Dose Expansion (Intervention Cohort 1)
  Dose expansion with BAY 3713372 monotherapy in selected participants with MTAP-deleted solid tumors.
• Experimental: Dose Expansion (Intervention Cohort 2)
  Dose expansion with BAY 3713372 monotherapy in participants with MTAP-deleted non-small cell lung cancer (NSCLC).
• Experimental: Dose Expansion (Intervention Cohort 3)
  Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted NSCLC.
• Experimental: Dose Expansion (Intervention Cohort 4)
  Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted NSCLC.
• Experimental: Dose Expansion (Intervention Cohort 5)
  Dose expansion with BAY 3713372 monotherapy in participants with MTAP-deleted pancreatic ductal adenocarcinoma (PDAC).
• Experimental: Dose Expansion (Intervention Cohort 6)
  Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted PDAC.
• Experimental: Window-of-opportunity trial in participants with MTAP-deleted GBM (Intervention Cohort 7)
  A surgical window-of-opportunity trial of BAY 3713372 alone in participants with MTAP-deleted glioblastoma (GBM).

Primary Outcome Measure

Dose Escalation (Master and Intervention Cohort 1): Number of participants with treatment-emergent adverse events (TEAEs) [ Time Frame: From the first administration of study intervention up to 30 days after the last dose of study intervention ]

Central Contacts

• Bayer Clinical Trials Contact
  (+)1-888-84 22937
  [email protected]

Locations (17)

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