Muscle Health Measurements Using Electrical Impedance Myography

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Beth Israel Deaconess Medical Center
Study ID
NCT07502989
Status
Recruiting
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Conditions

  • Congenital Myopathy
  • Distal Myopathy
  • Muscular Dystrophies
  • Myofibrillar Myopathy
  • Myopathies
  • Myopathy
  • Myositis

Eligibility Criteria

Sex
ALL
Age
18 Years - 89 Years
Healthy Volunteers
Accepted

Interventions

  • Electrical Impedance Myography — DEVICE
    EIM is an impedance-based technology in which an imperceptible, high-, multi-frequency (e.g., 1 kHz to 10 MHz) electrical current is applied across two electrodes; the resulting voltage signals are measured across two sense electrodes

Study Details

This study is being done to further develop a device, the mScan, to measure muscle health as compared to measurements of muscle health using MRI (magnetic resonance imaging). This device is held against the skin and uses Electrical Impedance Myography (EIM). EIM uses a very small, noninvasive (e.g. no needles), brief (about 6 seconds), and painless electrical current to measure the muscle. The investigators will look at how the mScan predicts the muscle measurements seen on MRI in people with and without muscle disease. The investigators hope that this can be used in the future as a quick, convenient and less time-consuming way than MRI to assess muscle health. This could be used to measure how well treatments for different muscle disorders are working over a period of time.

Key Dates

Start date
Apr 9, 2025
Status verified
Feb 2026
Primary completion
Jun 1, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Healthy Control
  • Arm: Myopathy
    Participants with Myopathies

Primary Outcome Measure

Pathology-specific penalized regression development. Predictive algorithms connecting EIM data sets to MRI outcomes representative of muscle pathology, including muscle cross-sectional area, fat content, edema, and fiber disorganization. [ Time Frame: Two years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Beth Israel Deaconess Medical CenterBostonMassachusetts02215
Amy Lewandowski
[email protected]
617-667-2545
Pushpa Narayanaswami, M.D. (PRINCIPAL_INVESTIGATOR)

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Beth Israel Deaconess Medical Center· Boston, MA

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