Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

80 locations incl. Chandler

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting

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A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

for Lupus Erythematosus, Systemic

Drug: Nipocalimab

29 locations incl. Beverly Hills

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 75

Code: NCT07438496·Phase 3·Recruiting

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Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

for Advanced Hepatocellular Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07042919·Phase 1, Phase 2·Not Yet Recruiting

A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

for Generalized Myasthenia Gravis

5 locations incl. Chicago

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07221838·Phase 4·Recruiting

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Efficacy and Safety of Ribupatide (KAI-9531) Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

35 locations incl. Mesa

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07458269·Phase 2·Enrolling By Invitation

ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

for Depression

2 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18 - 60

Code: NCT06408246·Phase 2·Recruiting

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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

18 locations incl. Alexander City

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting

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Chronic Low Back Pain and Osteopathic Manipulation Treatment

for Chronic Low Back Pain (CLBP)

1 location in Hines

Sponsor: Edward Hines Jr. VA Hospital

Sex: All·Age: 18+

Code: NCT07161661·Recruiting

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A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia

for Schizophrenia

8 locations incl. Garden Grove

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 55

Code: NCT07615426·Phase 1·Recruiting

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Non-invasive VNS for Parkinson's Gait

for Parkinson's Disease

1 location in Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 50 - 88

Code: NCT06562569·Recruiting

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Synergistic Minimally Invasive Surgery and Deferoxamine in ICH

for Intracerebral Hemorrhage

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 80

Code: NCT07162363·Phase 2, Phase 3·Not Yet Recruiting

FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

for Hypertension

4 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: All ages

Code: NCT07332741·Phase 2·Not Yet Recruiting

Diet Synergy in Muscle Protein Synthesis

for Muscle Protein Synthetic Response to Protein

2 locations incl. Urbana

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 19 - 40·Accepts healthy volunteers

Code: NCT07367854·Recruiting

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Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer

for Oropharyngeal Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07290621·Phase 2·Recruiting

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Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

13 locations incl. Los Angeles

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting

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COPD Exacerbation Follow Up

for COPD (Chronic Obstructive Pulmonary Disease)

4 locations incl. Park Ridge

Sponsor: Viz.ai, Inc.

Sex: All·Age: 40+

Code: NCT07118306·Recruiting

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An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

20 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Not Yet Recruiting

Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy

for Autoimmune Disorders

8 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT07103746·Phase 2·Recruiting

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Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

for Advanced Hepatocellular Carcinoma

107 locations incl. Berkeley

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07166406·Phase 3·Recruiting

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Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

for Primary Sjogren's Disease

Drug: Telitacicept

26 locations incl. Chandler

Sponsor: Vor Biopharma

Sex: All·Age: 18 - 75

Code: NCT07404865·Phase 3·Recruiting

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Zinc Supplementation With Botulinum Toxin for Overactive Bladder

for Overactive Bladder (OAB)

1 location in Skokie

Sponsor: Endeavor Health

Sex: Female·Age: 21 - 100

Code: NCT07405554·Phase 2·Recruiting

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A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants

for Healthy Volunteer

Drug: Upadacitinib

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07425899·Phase 1·Recruiting

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Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation

for Intracranial Aneurysm

6 locations incl. Jacksonville

Sponsor: Spryte Medical

Sex: All·Age: 18 - 75

Code: NCT07214220·Recruiting

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Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

for HIV-1-infection

11 locations incl. Los Angeles

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07293559·Recruiting

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

22 locations incl. Miramar

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting

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Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

11 locations incl. Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting

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A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

for Relapsed Refractory Multiple Myeloma

48 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07391657·Phase 3·Recruiting

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An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis

for Plaque Psoriasis

16 locations incl. Fountain Valley

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07449702·Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

for Locally Advanced Adrenal Cortical Carcinoma

Drug: Cabozantinib

69 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT06900595·Phase 2·Recruiting

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Mobilizing Community Hypertension Access Pilot

for Hypertension

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07547345·Recruiting

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A Clinical Study to Evaluate the Efficacy and Safety of Ultra in Promoting Hair Regrowth

for Androgenic Alopecia

2 locations incl. Glenview

Sponsor: CynosureLutronic

Sex: All·Age: 22 - 70

Code: NCT07588243·Recruiting

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A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

41 locations incl. Los Angeles

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting

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Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement

for Healthy Adult

1 location in Addison

Sponsor: Shaklee Corporation

Sex: All·Age: 45 - 65·Accepts healthy volunteers

Code: NCT07428889·Recruiting

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Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

for Pregnancy

8 locations incl. Los Angeles

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: Female·Age: All ages

Code: NCT07207876·Recruiting

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A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

65 locations incl. Alabaster

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting

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Empower EI: Comparing Early Intervention Approaches to Improve Communication in Toddlers With Developmental Delays

for Developmental Delays

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 12 Months - 31 Months

Code: NCT07227974·Recruiting

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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

for Diabetic Peripheral Neuropathic Pain

Drug: LY4065967

36 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07285018·Phase 2·Recruiting

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COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

50 locations incl. Bakersfield

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

18 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting

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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

309 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting

Apply to this trial