Zinc Supplementation With Botulinum Toxin for Overactive Bladder

Part of paid clinical trials in Skokie, Illinois.

Sponsor
Endeavor Health
Study ID
NCT07405554
Phase
PHASE2
Status
Recruiting
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Conditions

  • Overactive Bladder (OAB)

Eligibility Criteria

Sex
FEMALE
Age
21 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Zinc Citrate Oral Capsule — DRUG
    Zinc citrate 50mg combined with 7,500 phytase units in an oral capsule
  • Placebo — DRUG
    Placebo oral capsule

Study Details

This randomized, double-blind, placebo-controlled trial evaluates whether oral zinc plus phytase supplementation modifies clinical response to intradetrusor botulinum toxin injection in patients with overactive bladder. Participants will receive either zinc plus phytase supplementation or matching placebo for five days prior to intradetrusor botulinum toxin injection. Participants will be followed for six months after treatment to assess need for repeat botulinum toxin injection, urinary symptoms, and patient-reported outcomes related to overactive bladder.

Key Dates

Start date
Feb 26, 2026
Status verified
Feb 2026
Primary completion
May 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Zinc + Phytase Group
    Participants will receive zinc + phytase capsules for five days prior to the scheduled procedure date.
  • Placebo Comparator: Placebo Group
    Participants will receive placebo capsules for five days prior to the scheduled procedure date.

Primary Outcome Measure

Number of patients needing repeat intradetrusor botulinum toxin injection at 6 months [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Endeavor HealthSkokieIllinois60076
Ana Burgos, MD
[email protected]
847-570-4729
Ghazaleh Rostami Nia, MD (PRINCIPAL_INVESTIGATOR)
Ana Burgos, MD (SUB_INVESTIGATOR)

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