Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss

for Obesity and Obesity-related Medical Conditions

2 locations incl. Evanston

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06894498·Recruiting

Apply to this trial

Autonomic Neural Blockade in Bariatric Surgery

for Bariatric Surgery Candidate

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18 - 90

Code: NCT07104825·Not Yet Recruiting

Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)

for Long QT Syndrome (LQTS) 2

6 locations incl. Scottsdale

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 15+

Code: NCT07277582·Phase 2, Phase 3·Recruiting

Apply to this trial

Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome

for Aggressive Behavior in Fragile X Syndome

3 locations incl. Sacramento

Sponsor: Azevan Pharmaceuticals

Sex: Male·Age: 18 - 45

Code: NCT07328529·Phase 2·Not Yet Recruiting

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

for Schizophrenia

5 locations incl. Lemon Grove

Sponsor: MapLight Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07459647·Phase 2·Recruiting

Apply to this trial

Immune Modulation During Palynziq® Treatment in Adults (IMPALA)

for Phenylketonuria

12 locations incl. Los Angeles

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 18 - 65

Code: NCT07477691·Phase 4·Not Yet Recruiting

HCMR Re-Imaging Study

for Hypertrophic Cardiomyopathy (HCM)

6 locations incl. Evanston

Sponsor: Christopher Kramer

Sex: All·Age: 18 - 65

Code: NCT07054073·Recruiting

Apply to this trial

A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

for Cytomegalovirus Prophylaxis

16 locations incl. Birmingham

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: Up to 17

Code: NCT07199465·Phase 1·Recruiting

Apply to this trial

Nurse-Led PTSD Treatment in Primary Care

for Post Traumatic Stress Disorder PTSD

2 locations incl. Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07430657·Recruiting

Apply to this trial

Procedural Framing and Epidural Steroid Injection Outcomes

for Lumbosacral Radiculopathy

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: All ages

Code: NCT07498140·Recruiting

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A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

for Macular Degeneration

30 locations incl. Springdale

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07440225·Phase 2, Phase 3·Recruiting

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A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female Participants

for Healthy Volunteer

1 location in Grayslake

Sponsor: AbbVie

Sex: Female·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07502417·Phase 1·Recruiting

Apply to this trial

A Study of Methylprednisolone in People Having Liver Surgery

for Hepatectomy

19 locations incl. Chicago

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07507643·Phase 3·Recruiting

Apply to this trial

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis (UC)

Drug: LY4268989

49 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07415044·Phase 2·Recruiting

Apply to this trial

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

for Emphysema or COPD

3 locations incl. San Francisco

Sponsor: Pulmair Medical, Inc.

Sex: All·Age: 22+

Code: NCT07119229·Recruiting

Apply to this trial

Transition to KPL-387 Monotherapy Dosing & Administration Study

for Recurrent Pericarditis

14 locations incl. Phoenix

Sponsor: Kiniksa Pharmaceuticals International, plc

Sex: All·Age: 18 - 80

Code: NCT07288216·Phase 2·Recruiting

Apply to this trial

Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia

for Schizophrenia

13 locations incl. Bentonville

Sponsor: LB Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07363577·Phase 3·Recruiting

Apply to this trial

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

for Breast Neoplasms

39 locations incl. Birmingham

Sponsor: Natera, Inc.

Sex: All·Age: 18+

Code: NCT07214532·Recruiting

Apply to this trial

PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

for Proteinuric Kidney Diseases

25 locations incl. Huntsville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07355296·Phase 2·Recruiting

Apply to this trial

CApivasertib, Venetoclax And Low-intensity chemotheRapY for Adults With ALL/LBL

for Leukemia

Drug: Venetoclax

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07294677·Phase 1, Phase 2·Recruiting

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A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

for Adenovirus Infections

26 locations incl. Phoenix

Sponsor: SymBio Pharmaceuticals

Sex: All·Age: 2 Months+

Code: NCT07387367·Phase 3·Recruiting

Apply to this trial

Spasticity in SCI Following Acute Intermittent Hypoxia

for Spinal Cord Injuries (SCI)

1 location in Chicago

Sponsor: Zev Rymer

Sex: All·Age: 18+

Code: NCT07583498·Recruiting

Apply to this trial

The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

17 locations incl. Phoenix

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting

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A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

for Hepatocellular Carcinoma (HCC)

Drug: Ipilimumab

9 locations incl. Los Angeles

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07291076·Phase 1, Phase 2·Recruiting

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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

25 locations incl. Anniston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351045·Phase 3·Recruiting

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A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for Non-small Cell Lung Cancer (NSCLC)

Drug: Durvalumab

38 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361497·Phase 3·Recruiting

Apply to this trial

Acute Effects of Alpha-glycerylphosphorylcholine (A-GPC) on Lower Body Muscular Performance.

for Healthy Adult Participants

1 location in DeKalb

Sponsor: Northern Illinois University

Sex: Male·Age: 19 - 29·Accepts healthy volunteers

Code: NCT07397273·Not Yet Recruiting

Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia

for Schizophrenia

Drug: GXV813

7 locations incl. Bentonville

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07467993·Phase 2·Recruiting

Apply to this trial

Patient Quality of Recovery After TAVR With Different Sedation Regimens

for Transcatheter Aortic Valve Replacement (TAVR)

1 location in Glenview

Sponsor: David Lyubashevsky

Sex: All·Age: 18 - 90

Code: NCT07556523·Phase 4·Recruiting

Apply to this trial

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

for PROC

12 locations incl. Little Rock

Sponsor: Whitehawk Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07470853·Phase 1·Recruiting

Apply to this trial

Endotype DIrected Treatment for OSA in Down Syndrome

for Obstructive Sleep Apnea (OSA)

5 locations incl. Tucson

Sponsor: University of Arizona

Sex: All·Age: 6+

Code: NCT07280468·Phase 4·Recruiting

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Drug: Nivolumab

34 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221149·Phase 2, Phase 3·Recruiting

Apply to this trial

Long-Term Open-Label Extension Study of Oral Levosimendan

for Pulmonary Hypertension Associated With HFpEF

5 locations incl. Chicago

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: All ages

Code: NCT07436689·Phase 3·Enrolling By Invitation

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Pumitamig

40 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361510·Phase 3·Recruiting

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LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)

for Lung Cancer Screening

2 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07408531·Recruiting

Apply to this trial

A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder

for Muscle-invasive Bladder Cancer

9 locations incl. Little Rock

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07475806·Phase 2·Recruiting

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The SENTINL-1 Study: Evaluating Patient-Reported Outcomes of AI-Inferred Lung Cancer Risk

for Lung Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07458425·Recruiting

Apply to this trial

Achieving Routine Intervention and Screening for Emotional Health

for Type 2 Diabetes Mellitus (T2DM)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06887049·Recruiting

Apply to this trial

Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

52 locations incl. Tucson

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting

Apply to this trial

Implementation of Effective Hypertension Management Approaches: OSF HealthCare

for Uncontrolled Hypertension

1 location in Peoria

Sponsor: Colleen J Klein

Sex: All·Age: 18+

Code: NCT07450222·Enrolling By Invitation