HCMR Re-Imaging Study

Part of paid clinical trials in Evanston, Illinois.

Sponsor
Christopher Kramer
Study ID
NCT07054073
Status
Recruiting
Apply to this trial

Conditions

  • Hypertrophic Cardiomyopathy (HCM)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • None - observational study — OTHER
    None - observational study

Study Details

This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HCM causes the heart muscle to become thick, which can make the heart stiff and harder to work properly. It can also affect the heart's electrical system. This study is looking to enroll patients that were previously part of a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy." The results of that study are still being reviewed, but they might show that people who had a substance called Gadolinium (MRI contrast or dye) collected in their heart muscle may have a higher risk for heart problems, including sudden cardiac death. This is called "late gadolinium enhancement" (LGE). This study is aiming to do follow-up imaging on those patients to better understand how LGE affects people with HCM.

Key Dates

Start date
Mar 30, 2026
Status verified
Mar 2026
Primary completion
Mar 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
314 participants (estimated)

Arms

  • Arm: Obstructive HCM
  • Arm: Non-obstructive HCM

Primary Outcome Measure

Change in % LGE mass [ Time Frame: From baseline over a minimum of 7 years ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
NorthwesternEvanstonIllinois60208
Lubna Choudhury, MD
[email protected]
312-695-0059
Brigham & Women's HospitalBostonMassachusetts02115
Carolyn Ho, MD
[email protected]
617-732-5685
Tufts Medical CenterMedfordMassachusetts02155
Christopher Madias, MD
[email protected]
617-636-5902
University of MichiganAnn ArborMichigan48109
Adam Helms, MD
[email protected]
734-764-4500
Cleveland ClinicClevelandOhio44195
Milind Desai, MD
[email protected]
216-445-5250
University of VirginiaCharlottesvilleVirginia22903
Niki Sprouse
[email protected]
434-982-1058

Find similar trials in Evanston, IL

By research site
Northwestern· Evanston, ILBrigham & Women's Hospital· Boston, MATufts Medical Center· Medford, MAUniversity of Michigan· Ann Arbor, MICleveland Clinic· Cleveland, OHUniversity of Virginia· Charlottesville, VA

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