Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT02413450
Status
Enrolling By Invitation

Conditions

  • Arrhythmogenic Cardiomyopathy (AC, ARVD/C)
  • Brugada Syndrome (BrS)
  • Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
  • Dilated Cardiomyopathy (DCM)
  • Early Repolarization Syndrome (ERS)
  • Hypertrophic Cardiomyopathy (HCM)
  • Inherited Cardiac Arrythmias
  • Long QT Syndrome (LQTS)
  • Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy)
  • Normal Control Subjects

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Study Details

Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and phenotypic variability, with applications in personalized predictive pharmacology/toxicology, cell therapy and regenerative medicine. This research will collect blood or skin biopsies from patients and healthy controls for the purpose of generating cell and tissue models of Mendelian heritable forms of heart disease focusing on cardiomyopathies, channelopathies and neuromuscular diseases. Cardiomyocytes derived from hiPSCs will provide a ready source of disease specific cells to study pathogenesis and therapeutics.

Key Dates

Start date
Aug 31, 2013
Status verified
Jan 2026
Primary completion
Aug 31, 2030
Completion
Aug 31, 2031

Study Design

Enrollment
100 participants (estimated)

Primary Outcome Measure

•Production of cardiomyocytes and engineered tissues from hiPSC-derived cardiomyocytes to be used in mechanistic studies of disease and testing of therapeutic interventions. [ Time Frame: 10 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins Medical InstituteBaltimoreMaryland21287-9106-

Find similar trials in Baltimore, MD

By research site
Johns Hopkins Medical Institute· Baltimore, MD

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