Spasticity in SCI Following Acute Intermittent Hypoxia

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Zev Rymer
Study ID
NCT07583498
Status
Recruiting
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Conditions

  • Spinal Cord Injuries (SCI)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acute Intermittent Hypoxia (AIH) — DEVICE
    This intervention involves breathing lowered levels of oxygen for 60 seconds, alternating with 60 seconds of room air breathing. Participants will be monitored and observed during the entire session for any changes in vital signs

Study Details

This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.

Key Dates

Start date
Mar 17, 2026
Status verified
May 2026
Primary completion
Mar 31, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: AIH intervention
    In this Arm, participants will receive the Acute Intermittent Hypoxia Intervention. In this AIH, participants will breath alternating bouts of lowered oxygen and room air (approximately 60 seconds of each) for around 30 minutes.

Primary Outcome Measure

Change in reflex indentation threshold [ Time Frame: Day 1 of Intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Shirley Ryan AbilityLabChicagoIllinois60611
Alexander Barry, MS
[email protected]
312-238-1435
William z Rymer, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chicago, IL

By research site
Shirley Ryan AbilityLab· Chicago, IL

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