Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

for Glioblastoma Multiforme of Brain

3 locations incl. Tampa

Sponsor: Tetragon Biosciences Ltd

Sex: All·Age: 18+

Code: NCT07464925·Phase 1·Recruiting

Apply to this trial

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

19 locations incl. Escondido

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07509307·Phase 3·Recruiting

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A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Drug: NNC0662-0419

23 locations incl. Lancaster

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07415954·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of Hetrombopag Olamine Tablets Vs Placebo in Patients With Chemotherapy-Induced Thrombocytopenia

for Patients With Chemotherapy-Induced Thrombocytopenia

7 locations incl. Los Alamitos

Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Sex: All·Age: 18+

Code: NCT07286032·Phase 3·Recruiting

Apply to this trial

Novel Stretching Device Versus Night Splints

for Plantar Fasciitis

1 location in Carterville

Sponsor: SAE Orthopedics

Sex: All·Age: 18+

Code: NCT05216679·Recruiting

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Epcoritamab, Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Salvage Therapy Before Autologous Stem Cell Transplant for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Epcoritamab

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07365306·Phase 2·Recruiting

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A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

for Macular Degeneration

9 locations incl. Mountain View

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07496567·Phase 2, Phase 3·Recruiting

Apply to this trial

Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

for Weight Regain

9 locations incl. Irvine

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07015424·Recruiting

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Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

for Complex Regional Pain Syndrome Type I

12 locations incl. Phoenix

Sponsor: Ambros Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07210515·Phase 3·Recruiting

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N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy

for Myxoid Liposarcoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT07261657·EARLY_Phase 1·Recruiting

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PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

for Atrial Fibrillation (AF)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 60 - 99

Code: NCT07324772·Not Yet Recruiting

A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

25 locations incl. Anniston

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT07430306·Phase 3·Recruiting

Apply to this trial

Choice and Autonomy in Learning Mindfulness for Pediatric Residents

for Program Engagement

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07542769·Recruiting

Apply to this trial

Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus

for Type I Diabetes

5 locations incl. Birmingham

Sponsor: Op-T LLC

Sex: All·Age: 18 - 50

Code: NCT06964087·Phase 2·Recruiting

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Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile

for Hypercholesterolemia

1 location in Addison

Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Sex: All·Age: 18 - 74·Accepts healthy volunteers

Code: NCT07514663·Recruiting

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Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

for Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)

Drug: Empagliflozin

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 60

Code: NCT07175051·Phase 2·Recruiting

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

13 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting

Apply to this trial

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

for Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

5 locations incl. Irvine

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07403721·Phase 1·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

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Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

for Obesity

19 locations incl. Chandler

Sponsor: Kailera

Sex: All·Age: 18 - 75

Code: NCT07497880·Phase 2·Recruiting

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Experimental Evidence of the Impact of Parental Income on Child Mental Health and Neuroimmune Function

for Psychopathology

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 10 - 18

Code: NCT07641244·Recruiting

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Extensively Hydrolyzed Formula Growth Monitioring Study (GMS)

for Growth

12 locations incl. Birmingham

Sponsor: Mead Johnson Nutrition

Sex: All·Age: 10 Days - 14 Days·Accepts healthy volunteers

Code: NCT07513506·Not Yet Recruiting

Acute Amino Acid Response of Proprietary Beverages

for Healthy

2 locations incl. Addison

Sponsor: Shaklee Corporation

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07534020·Recruiting

Apply to this trial

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

for Post Traumatic Stress Disorder

26 locations incl. Little Rock

Sponsor: Transcend Therapeutics

Sex: All·Age: 18+

Code: NCT07456696·Phase 3·Recruiting

Apply to this trial

Second Line Endovascular Treatment in Acute DVT

for Deep Venous Thrombosis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 75

Code: NCT06486181·Phase 4·Not Yet Recruiting

Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD

for PTSD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06570213·EARLY_Phase 1·Recruiting

Apply to this trial

Cognitive-Sensorimotor Function in Long-COVID

for Post-acute Sequelae of SARS-CoV-2 Infection

1 location in Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06850350·Recruiting

Apply to this trial

A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy for Dizziness

for Dizziness

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07225023·Recruiting

Apply to this trial

Behavioral Economic Attributes of Recreation

for Cardiometabolic Health Indicators

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07282418·Phase 1, Phase 2·Recruiting

Apply to this trial

Monitoring Occupational Dental Stress Using Apple Watch

for Occupational Stress

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07356141·Not Yet Recruiting

We Need to FEED: Facilitating Enteral Education for Discharge

for Enteral Nutrition Feeding

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: Up to 17

Code: NCT07383272·Not Yet Recruiting

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

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A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

18 locations incl. Orange

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting

Apply to this trial

Achilles Tendinopathy Embolization

for Achilles Tendinopathy (AT)

1 location in Libertyville

Sponsor: Joint & Vascular Institute

Sex: All·Age: 25 - 80

Code: NCT07477860·Phase 1·Recruiting

Apply to this trial

Apple Watch Evaluation of Endodontics Occupational Stress

for Occupational Stress

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07498348·Not Yet Recruiting

Prospective Randomized Trial Comparing Longitudinal vs. Transverse A1 Pulley Release

for Trigger Finger

2 locations incl. Chicago

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07516652·Recruiting

Apply to this trial

Sun Exposure and Activities After Skin Cancer: Optimization of mHealth Interventions

for Melanoma (Skin Cancer)

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07556380·Not Yet Recruiting

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

for Distal Radius Fracture

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05318729·Not Yet Recruiting