AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Part of paid clinical trials in Escondido, California.

Sponsor
Novo Nordisk A/S
Study ID
NCT07509307
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • NNC0487-0111 — DRUG
    NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
  • Placebo (matched to NNC0487-0111) — DRUG
    Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Study Details

This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Key Dates

Start date
Apr 20, 2026
Status verified
Jun 2026
Primary completion
Aug 14, 2028
Completion
Aug 14, 2028

Study Design

Enrollment
400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NNC0487-0111
    Participants will be randomized to receive 1 of the 2 dose levels of NNC0487-0111 subcutaneously once weekly as an adjunct to a reduced-calorie diet and increased physical activity.
  • Placebo Comparator: Placebo
    Participants will receive placebo matched to NNC0487-0111 subcutaneously once weekly as an adjunct to a reduced-calorie diet and increased physical activity.

Primary Outcome Measure

Relative change in body weight [ Time Frame: From baseline (week 0) to week 80 ]

Central Contacts

Locations (19)

FacilityCityStateZIPSite coordinators
Neighborhood HealthcareEscondidoCalifornia92025-
First Valley Medical GroupLancasterCalifornia93534-
Desert Oasis HealthcarePalm SpringsCalifornia92262-
Chase Medical Research LLCWaterburyConnecticut06708-
CNS HealthcareJacksonvilleFlorida32256-
Westside Center For Clinical ResearchJacksonvilleFlorida32205-
Advanced Res for Health ImproveNaplesFlorida34102-
Clinical Investigation Spec GurneeGurneeIllinois60031-
Evanston Premier Hlthcr ResSkokieIllinois60077-
Monroe Biomedical Research, LLCLouisvilleKentucky40213-
Arcturus Healthcare, PLC.TroyMichigan48098-6368-
Clinvest ResearchSpringfieldMissouri65807-
Hospital For Special SurgeryNew YorkNew York10021-
NYU Langone Orthopedic CenterNew YorkNew York10016-
Piedmont Healthcare/ResearchStatesvilleNorth Carolina28625-
Northwest Research CenterPortlandOregon97202-
Mercy Family ClinicDallasTexas75208-
Health Res of Hampton RoadsNewport NewsVirginia23606-
Northwest Clinical Research CenterBellevueWashington98007-

Find similar trials in Escondido, CA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Neighborhood Healthcare· Escondido, CAFirst Valley Medical Group· Lancaster, CADesert Oasis Healthcare· Palm Springs, CAChase Medical Research LLC· Waterbury, CTCNS Healthcare· Jacksonville, FLWestside Center For Clinical Research· Jacksonville, FL

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