Diet Synergy in Muscle Protein Synthesis

Part of paid clinical trials in Urbana, Illinois.

Sponsor
University of Illinois at Urbana-Champaign
Study ID
NCT07367854
Status
Recruiting
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Conditions

  • Isotope Labeling
  • Muscle Health
  • Muscle Protein Synthesis
  • Muscle Protein Synthetic Response to Protein
  • Protein Metabolism
  • Recreational Activities

Eligibility Criteria

Sex
ALL
Age
19 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Resistance Exercise — BEHAVIORAL
    Participants will perform leg press and leg extension immediately prior to ingestion of either potato-beef combination, bread-beef combination, or beef alone.
  • Potato and Beef — DIETARY_SUPPLEMENT
    Participants will ingest baked russet potato and cooked ground beef immediately after resistance exercise.
  • Bread and Beef — DIETARY_SUPPLEMENT
    Participants will ingest white bread and cooked ground beef immediately after resistance exercise.
  • Beef — DIETARY_SUPPLEMENT
    Participants will ingest cooked ground beef immediately after resistance exercise.

Study Details

In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat/7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.

Key Dates

Start date
Mar 1, 2026
Status verified
Mar 2026
Primary completion
Oct 31, 2027
Completion
Nov 1, 2028

Study Design

Enrollment
15 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Potato and Beef (PB)
    Participants will ingest 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 37 g carbohydrate, 5 g fat, 4 g fiber) after resistance exercise.
  • Experimental: Bread and Beef (BB)
    Participants will ingest 2 slices white bread and 2 ounce-equivalent lean ground beef combination (262 kcals, 19.8 g protein, 28 g carbohydrate, 6.8 g fat, 1.8 g fiber) after resistance exercise.
  • Experimental: Beef (B)
    Participants will ingest 2 ounce-equivalent lean ground beef (110 kcals, 14.8 g protein, 5 g fat) after resistance exercise.

Primary Outcome Measure

Myofibrillar protein fractional synthesis rate [ Time Frame: Baseline muscle biopsy (-150 minutes), Postabsorptive muscle biopsy (-30 minutes), and Postprandial muscle biopsy (300 minutes) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Louise Freer HallUrbanaIllinois61801
Nicholas A Burd (Full Professor), PhD
[email protected]
2172440970
Calvin Chen, PhD Student
[email protected]
2173906655
Nicholas A Burd, PhD (PRINCIPAL_INVESTIGATOR)
Louise Freer HallUrbanaIllinois61801
Calvin Wei-Ting Chen
[email protected]
2173906655
Nicholas A. Burd, PhD (PRINCIPAL_INVESTIGATOR)

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