Stable Isotopes- Adults With Obesity

Part of paid clinical trials in Urbana, Illinois.

Sponsor
University of Illinois at Urbana-Champaign
Study ID
NCT07020741
Status
Recruiting
Apply to this trial

Conditions

  • Glucose Metabolism
  • Obese Patients (BMI ≥ 30 kg/m²)
  • Protein Metabolism

Eligibility Criteria

Sex
ALL
Age
19 Years - 59 Years
Healthy Volunteers
Accepted

Interventions

  • Indispensable Amino Acid Oxidation — PROCEDURE
    Participants will ingest six hourly meals designed to provide 50% of the daily intake of 1.1 g·kgLBM. Additional energy (1.5x daily resting metabolic rate), carbohydrate (55%), and fat (35%) will be provided in beverages and protein-free cookies (for palatability). The first drink will contain priming doses of NaH13CO2 (0.176 mg·kg-1), \[13C\]phenylalanine (1.86 mg·kg-1), \[2H5\]phenylalanine (0.34 mg·kg-1) with all subsequent drinks containing 1.2 mg·kg-1 \[13C\]phenylalanine and 0.51 mg·kg-1 \[2H5\]phenylalanine.
  • Stable Isotope Oral Glucose Tolerance Test — PROCEDURE
    Participants will consume a 75g glucose drink dissolved in 250 ml of water enriched with \[6,6\_2H2\]glucose and \[13C6\]glucose.

Study Details

In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.

Key Dates

Start date
Sep 12, 2025
Status verified
Jun 2025
Primary completion
Aug 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
8 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: IAAO
    Participants will ingest a series of 6 hourly beverages containing 50% of the daily intake of 1.1g/kg/day
  • Experimental: SIOGTT
    Participants will consume one 75g glucose drink dissolved in 250 ml of water.

Primary Outcome Measure

Define obesity-related whole body protein efficiency based of the IAAO method [ Time Frame: 0 - 6 hours observational period ingesting six hourly meals, within 1 week of preliminary testing. Baseline measures taken at --30 minutes. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Freer Hall - University of IllinoisUrbanaIllinois61801
Nicholas Burd (Associate Professor), PhD
[email protected]
2172440970
Gena L Irwin Research Assistant, M.S
[email protected]
3608883281
Nicholas Burd, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Freer Hall - University of Illinois· Urbana, IL

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