Prandial Metabolic Phenotype in Adults

Part of paid clinical trials in College Station, Texas.

Sponsor
Texas A&M University
Study ID
NCT05400733
Status
Recruiting
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Conditions

  • Protein Metabolism

Eligibility Criteria

Sex
ALL
Age
60 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Total Amino Acids — DIETARY_SUPPLEMENT
    Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Alanine, Arginine, Aspartate, Cystine, Glutamine, Glutamate, Glycine, Proline, Serine, Tyrosine. All supplements are commercially available.
  • Essential Amino Acids — DIETARY_SUPPLEMENT
    Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
  • Essential Amino Acids + Hydroxy-methylbutyric acid (HMB) — DIETARY_SUPPLEMENT
    Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, HMB. All supplements are commercially available.
  • Essential Amino Acids + Leucine — DIETARY_SUPPLEMENT
    Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Extra leucine. All supplements are commercially available.
  • Essential Amino Acids High — DIETARY_SUPPLEMENT
    Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
  • Placebo Water — DIETARY_SUPPLEMENT
    Water

Study Details

Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.

Key Dates

Start date
Jun 24, 2022
Status verified
Sep 2025
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Other: Healthy male older adults
    Healthy male older adults
  • Other: Healthy female older adults
    Healthy female older adults

Primary Outcome Measure

Feeding related changes in whole-body protein and amino acid metabolism [ Time Frame: up to 6 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Human Clinical Research FacilityCollege StationTexas77843
Marielle Engelen, Ph.D.
[email protected]
Marielle Engelen, Ph.D. (PRINCIPAL_INVESTIGATOR)
Nicolaas E Deutz, Ph.D. (PRINCIPAL_INVESTIGATOR)

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Human Clinical Research Facility· College Station, TX

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