Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Part of paid clinical trials in College Station, Texas.

Sponsor
Texas A&M University
Study ID
NCT06628349
Status
Recruiting
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Conditions

  • Protein Metabolism

Eligibility Criteria

Sex
ALL
Age
50 Years - 95 Years
Healthy Volunteers
Accepted

Interventions

  • Whey Protein Isolate 90% — DIETARY_SUPPLEMENT
    Commercially available animal based protein powders
  • Soy Protein Isolate (90% Protein) — DIETARY_SUPPLEMENT
    Commercially available plant based protein powders
  • Organic Pea Protein Isolate — DIETARY_SUPPLEMENT
    Commercially available plant based protein powders
  • Placebo (Water) — DIETARY_SUPPLEMENT
    Normal drinking water

Study Details

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Key Dates

Start date
Feb 1, 2024
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Healthy male older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: Healthy female older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: Healthy male old older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: Healthy female old older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: Sarcopenic male old older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: Sarcopenic female old older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: COPD male older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water
  • Experimental: COPD female older adults
    Dietary Supplement: Whey Protein Isolate 90%. Commercially available Dietary Supplement: Soy Protein Isolate (90% Protein). Commercially available Dietary Supplement: Organic Pea Protein Isolate. Commercially available Dietary Supplement: Placebo - Water

Primary Outcome Measure

Protein and amino acid synthesis capacity of plant-based and animal-based protein in older adults with or without sarcopenia measured by the use of stable isotope tracers [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Texas A&M University - CTRALCollege StationTexas77845
Laura Ruebush
[email protected]
979-218-5515
Nicolaas E Deutz, MD, PhD (PRINCIPAL_INVESTIGATOR)
Marielle P Engelen, PhD (SUB_INVESTIGATOR)

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Texas A&M University - CTRAL· College Station, TX

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