Paid Clinical Trials in Greenville, SC
As of June 2026, 305 paid clinical trials are recruiting in Greenville, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Greenville offers studies at sites including Prisma Health Cancer Institute - Faris for conditions such as Acute Myeloid Leukemia, Breast Cancer, Heart Failure, Advanced Solid Tumor. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Greenville
Trials by drug in Greenville
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305 clinical trials
↓ Download CSVPharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants
The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Phase 1/2 Study of KK2430 in Participants With Hematologic Neoplasms
A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight
A Phase 1 Study of the Safety and Tolerability of CTX-10726
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Implementation Facilitation of Exercise is Medicine Greenville
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
EVERO Drug-coated Balloon (DCB) Randomized Trial
Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices
Continuous Dual Aspiration Technique With Zoom System for Stroke
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Efficacy and Safety of Ribupatide (KAI-9531) Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes
Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer
COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
Dietary Insights and Nutrition Experiences in Adults on GLP-1 Therapy - A Study on Diet Quality Changes in Adults on GLP-1 Therapy
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
Solv Multi-Pass Hemodialysis System In-Center Clinical Study
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain
Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study
About research studies in Greenville
Greenville has approximately 305 recruiting research studies across a wide range of therapeutic areas. South Carolina hosts a diverse network of universities, academic medical centers, and community hospitals that run clinical trials across oncology, cardiology, neurology, and many other therapeutic areas.
Top Research Study Locations in Greenville
Researchers run research studies in Greenville, SC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Prisma Health Cancer Institute - Faris | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer | 57 |
| Prisma Health Cancer Institute - Eastside | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer | 56 |
| Prisma Health Cancer Institute - Butternut | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 48 |
| BI-LO Charities Children's Cancer Center | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Down Syndrome | 32 |
| Prisma Health | Abdominal Aortic Aneurysm, End Stage Renal Disease, AML | 28 |
| Prisma Health Greenville Memorial Hospital | Malignant Solid Neoplasm, Melanoma, Stage IV Breast Cancer AJCC v6 and v7 | 27 |
| Saint Francis Cancer Center | Anatomic Stage IV Breast Cancer AJCC v8, Melanoma, Breast Cancer | 26 |
| Saint Francis Hospital | Anatomic Stage IV Breast Cancer AJCC v8, Breast Carcinoma, Lung Non-Small Cell Carcinoma | 22 |
| Tribe Clinical Research, LLC | Obesity, Overweight, Atopic Dermatitis | 10 |
| Prisma Health - Upstate | Acute Myocardial Infarction, Acute Stroke, Chronic Disease | 9 |
| Prisma Health Cancer Institute | Advanced Melanoma, Advanced Solid Tumor, Amyloid Cardiomyopathy | 9 |
| Prisma Health Upstate | Acute Limb Ischemia, Chronic Graft-versus-host-disease, Deep Venous Thrombosis | 7 |
| Prisma Health-Upstate | AAA - Abdominal Aortic Aneurysm, AV Block, Advanced Solid Tumor | 6 |
| PCPMG Clinical Research Unit, LLC | Chronic Pain, Chronic Leg Pain, Chronic Low-back Pain | 4 |
| Tribe Clinical Research LLC | Cardiovascular Diseases, Chronic Spontaneous Urticaria (CSU), Diabetes Mellitus, Type 2 | 4 |
| Greenwood Genetic Center - Greenville | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 4 |
| Premier Neurology | Multiple Sclerosis (MS) Primary Progressive, Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis (SPMS) | 4 |
| Gastroenterology Associates | Crohn's Disease, Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis | 3 |
| Prisma Health- Upstate | Articular Fractures, Chronic Renal Disease, End Stage Renal Disease (ESRD) | 3 |
| Bon Secours - St. Francis Hospital | Breast Cancer, Muscle-invasive Urothelial Carcinoma | 2 |
| Bon Secours Medical Group Greenville Specialty Care, LLC | Heart Failure | 2 |
| GSK Investigational Site | Chickenpox, Neoplasms, Head and Neck | 2 |
| Gastroenterology Associates - Patewood | Obesity or Overweight, Crohn's Disease, Ulcerative Colitis | 2 |
| Greenville Hospital System University Medical Center (ITOR) | Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma, Solid Tumor | 2 |
| Greenville Memorial Hospital | Alcohol Use Disorder, Symptomatic Hypertrophic Cardiomyopathy (HCM) | 2 |
Active & Upcoming Studies in Greenville (2026)
Recruiting trials in Greenville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (121 active studies)
- A Phase 1 Study of the Safety and Tolerability of CTX-10726 · Phase 1 · Compass Therapeutics
- Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII · Phase 2 · Black Diamond Therapeutics, Inc.
Diabetes & metabolic (20 active studies)
- A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight · Phase 2 · Eli Lilly and Company
- A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight · Phase 3 · Novo Nordisk A/S
Neurology & pain (20 active studies)
- Continuous Dual Aspiration Technique With Zoom System for Stroke · Imperative Care, Inc.
- A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis · Phase 3 · Zenas BioPharma (USA), LLC
Cardiovascular (15 active studies)
- Implementation Facilitation of Exercise is Medicine Greenville · University of South Carolina
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
Mental health & behavior (5 active studies)
- Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine · Prisma Health-Upstate
- STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking · Medical University of South Carolina
Vaccines (4 active studies)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose · Phase 3 · Pfizer
Eye & vision (3 active studies)
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio · Phase 2 · Apellis Pharmaceuticals, Inc.
Pediatric (2 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Greenville
- Acute Myeloid Leukemia (9 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (8 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (7 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Advanced Solid Tumor (6 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Cancer (6 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Obesity (6 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
Leading research sponsors in Greenville
- National Cancer Institute (NCI)
- Children's Oncology Group
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- AstraZeneca
Local regulations and guidelines
Clinical trials in South Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. South Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Greenville. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Greenville
Hipa.ai aggregates every recruiting study in Greenville from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Greenville?
There are approximately 305 recruiting clinical trials in Greenville, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Greenville pay participants?
Most recruiting trials in Greenville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Greenville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Greenville?
The most common conditions under active study in Greenville include Acute Myeloid Leukemia (9), Breast Cancer (8), Heart Failure (7), Advanced Solid Tumor (6), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Greenville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Greenville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Greenville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Greenville?
Recruiting research sites in Greenville include Prisma Health Cancer Institute - Faris, Prisma Health Cancer Institute - Eastside, Prisma Health Cancer Institute - Butternut, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Greenville right now?
The largest active categories in Greenville are Cancer & tumors (121), Diabetes & metabolic (20), Neurology & pain (20). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.