Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

Conditions

• Sweet Non-cooling EC
• Sweet-Cooling EC
• Tobacco-flavored EC

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Brief individual counseling sessions — BEHAVIORAL
  Five brief, individual counseling sessions will provide education, behavioral support, and motivational strategies to facilitate switching from combustible cigarette use to EC

Study Details

This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine

Key Dates

Start date

Apr 29, 2026

Status verified

May 2026

Primary completion

Mar 30, 2029

Completion

Jun 29, 2029

Study Design

Enrollment

90 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Sweet-Cooling EC + Counseling
  Those randomized to the intervention group will be provided a free 12-week supply of sweet-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.
• Experimental: Sweet non-cooling EC + Counseling
  Those randomized to the intervention group will be provided a free 12-week supply of sweet non-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.
• Active Comparator: Tobacco-flavored EC + Counseling
  Those randomized to the intervention group will be provided a free 12-week supply of tobacco-flavored electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.

Primary Outcome Measure

Change in cigarettes smoked per day [ Time Frame: Baseline to week 12 ]

Central Contacts

• Irene Pericot-Valverde, PhD
  (864)656-4467
  [email protected]

Locations (1)

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