Paid Clinical Trials in Durham, NC

As of June 2026, 1,084 paid clinical trials are recruiting in Durham, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,084 clinical trials

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Randomized Study in Children and Adolescents With Migraine: Acute Treatment

for Pediatric Migraine

169 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 6 - 17

Code: NCT04649242·Phase 3·Recruiting

Apply to this trial

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

for Vulvar Cancer

21 locations incl. Orange

Sponsor: University Medical Center Groningen

Sex: Female·Age: 18+

Code: NCT05076942·Phase 2·Recruiting

Apply to this trial

Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

for Intraabdominal Hypertension

9 locations incl. Los Angeles

Sponsor: Potrero Medical

Sex: All·Age: 18+

Code: NCT04669548·Recruiting

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Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

for Heart Failure With Preserved Ejection Fraction (HFpEF

20 locations incl. Birmingham

Sponsor: Axon Therapies, Inc.

Sex: All·Age: 40+

Code: NCT04592445·Recruiting

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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

202 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting

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Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD)

for FSHD

16 locations incl. Los Angeles

Sponsor: University of Kansas Medical Center

Sex: All·Age: All ages

Code: NCT04635891·Recruiting

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

68 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting

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A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

for End Stage Renal Disease (ESRD)

21 locations incl. Phoenix

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 90

Code: NCT04671771·Recruiting

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Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

for Advanced Non-Small Cell Lung Cancer

Drug: Adagrasib

220 locations incl. Goodyear

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT04613596·Phase 2, Phase 3·Recruiting

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ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

for Transthyretin-Mediated Amyloidosis

13 locations incl. La Jolla

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: All ages

Code: NCT04561518·Recruiting

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Adherus™ Dural Sealant in Spinal Procedures

for Spinal Duraplasty

14 locations incl. Duarte

Sponsor: Stryker Craniomaxillofacial

Sex: All·Age: 18 - 75

Code: NCT04498026·Enrolling By Invitation

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

for Liver Cancer

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04933435·Recruiting

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

32 locations incl. Irvine

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting

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A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

for Solid Tumor

8 locations incl. Aurora

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT04516447·Phase 1·Recruiting

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Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy

for Sickle Cell Disease

15 locations incl. Birmingham

Sponsor: Genetix Biotherapeutics Inc.

Sex: All·Age: 2 - 53

Code: NCT04628585·Enrolling By Invitation

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

31 locations incl. Birmingham

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

177 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting

Apply to this trial

Going Places: A Multi-level Intervention to Improve Youth Transportation Efficacy and Physical Activity

for Physical Activity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 12 - 18

Code: NCT07044375·Enrolling By Invitation

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

for Glioblastoma

14 locations incl. Birmingham

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 6 Months - 25

Code: NCT04323046·Phase 1·Recruiting

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Ferritin and Iron Burden in SAH sIRB

for SAH

2 locations incl. Iowa City

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT03754725·Phase 1, Phase 2·Recruiting

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Lumbar Interbody Implant Study

for Degenerative Disc Disease

16 locations incl. La Jolla

Sponsor: NuVasive

Sex: All·Age: 18+

Code: NCT04418830·Enrolling By Invitation

Neural Correlates of Real World Spatial Navigation in Humans

for Memory, Delayed

2 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 12 - 70·Accepts healthy volunteers

Code: NCT04874220·Recruiting

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ROSE-Longitudinal Assessment With Neuroimaging

for Intracerebral Hemorrhage

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT05089331·Recruiting

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GSD VI and GSD IX Natural History

for Glycogen Storage Disease VI

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT04454216·Recruiting

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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

for Dravet Syndrome

31 locations incl. Birmingham

Sponsor: Epygenix

Sex: All·Age: 2+

Code: NCT04462770·Phase 3·Recruiting

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

539 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

13 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting

Apply to this trial

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

185 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting

Apply to this trial

ADRC Clinical Cohort (Alzheimer's Disease)

for Alzheimer Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 25 - 80·Accepts healthy volunteers

Code: NCT06703541·Recruiting

Apply to this trial

Cervical Interbody Implant Study

for Degenerative Disc Disease

7 locations incl. Orange

Sponsor: NuVasive

Sex: All·Age: 18+

Code: NCT04689854·Enrolling By Invitation

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

for Pancreatic Neoplasm

408 locations incl. Birmingham

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 50 - 75

Code: NCT04239573·Recruiting

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

1150 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting

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Tranexamic Acid to Reduce Blood Loss in Spine Surgery

for Spinal Injuries

4 locations incl. San Francisco

Sponsor: Columbia University

Sex: All·Age: 18 - 80

Code: NCT02314988·Phase 2, Phase 3·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

for Gastric Cancer

10 locations incl. Santa Monica

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT04379596·Phase 2·Recruiting

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Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers

for Metastatic Small Intestinal Adenocarcinoma

536 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04205968·Phase 2·Recruiting

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A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention

for Acute Kidney Injury

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 1 - 18

Code: NCT04403633·Recruiting

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A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

for Myelodysplastic Syndromes

Drug: Venetoclax

24 locations incl. Los Angeles

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04256317·Phase 2, Phase 3·Recruiting

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Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

for Prostate Adenocarcinoma

Drug: Apalutamide

345 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT04134260·Phase 3·Recruiting

Apply to this trial