Neural Correlates of Real World Spatial Navigation in Humans

Part of paid clinical trials in Los Angeles, California.

Sponsor
Duke University
Study ID
NCT04874220
Status
Recruiting
Apply to this trial

Conditions

  • Memory, Delayed

Eligibility Criteria

Sex
ALL
Age
12 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Deep Brain Stimulation — DEVICE
    Deep brain stimulation will be used
  • Memory and spatial navigation tasks — BEHAVIORAL
    Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity.
  • Physiological Signals — BEHAVIORAL
    Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used.
  • Questionnaires and Assessments — BEHAVIORAL
    Participants complete questionnaires and assessments to assess subjective emotional experience.

Study Details

The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.

Key Dates

Start date
Sep 30, 2020
Status verified
Jul 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: RNS Participants
    Subjects with RNS implants.

Primary Outcome Measure

Spatial memory [ Time Frame: Throughout study completion, an average of 2-4 days per year ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90024
Sonja Hiller
[email protected]
310-794-7517
Nanthia Suthana, PhD (PRINCIPAL_INVESTIGATOR)
Duke UniversityDurhamNorth Carolina27705
Gabriela Vilchez
[email protected]
919-681-2577
Nanthia Suthana, PhD (PRINCIPAL_INVESTIGATOR)

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