ADRC Clinical Cohort (Alzheimer's Disease)

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT06703541
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
25 Years - 80 Years
Healthy Volunteers
Accepted

Study Details

The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment, or a dementia diagnosis. Initial data including demographics, medical and family history, physical exam, and neuropsychological testing will be obtained. Participants will be asked to contribute a blood sample, a urine sample, a cerebrospinal fluid sample, and undergo a MRI scan. The cohort ages 45 to 80 will be seen yearly until death to evaluate medical status, undergo neuropsychological testing and possibly collect additional samples or undergo additional imaging. All data will be de-identified and stored by the ADRC. The purpose of this study is to examine normal cognition, mild cognitive impairment and Alzheimer's disease and related dementias (ADRD) as people get older. The investigators also hope to be able to assess risk factor information of the role of genes and environmental exposures (for example health conditions, diet, and medications) in Alzheimer's disease and related disorders (ADRD) and other conditions of aging. The biological samples collected in the study will create a repository. A repository is a collection of blood and tissue samples from people with certain diseases and conditions. For the purpose of this research, the investigators hope to help researchers learn more about Alzheimer's disease and related disorders and other conditions of aging.

Key Dates

Start date
Jul 21, 2020
Status verified
Aug 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Participants aged 25-44
    Subjects ages 25 to 44 at enrollment with normal cognition will undergo baseline visits including: * Demographics * Family history, medical history, current medications * General physical and neurological exam, sensory and motor testing * Vital signs * Blood sample collected for PT/INR, blood count, genetic testing, and storage for future unspecified research on cognition and disorders associated with altered cognition * Urine sample * Neuropsychological testing * Retinal imaging * Testing of memory, thought processes, and recognition * MRI * Lumbar puncture
  • Arm: Participants aged 45-80
    Subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment, or dementia will undergo baseline visits including: * Demographics and project partner demographics * Family history, medical history, current medications * General physical and neurological exam, sensory and motor testing * Vital signs * Blood sample collected for PT/INR, blood count, genetic testing, and storage for future unspecified research on cognition and disorders associated with altered cognition * Urine sample * Neuropsychological testing * Retinal imaging * Testing of memory, thought processes, and recognition * MRI * Lumbar puncture Participants will be asked to participate in yearly evaluations until the time of death. Participants can withdraw at any time.

Primary Outcome Measure

Number of participants enrolled who are aged 25 to 44 with normal cognition [ Time Frame: Until the end of the study, approximately 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke UniversityDurhamNorth Carolina27705
Rachel Dewees, MSW
[email protected]
919-660-2340
Heather E Whitson, MD, MHS (PRINCIPAL_INVESTIGATOR)
Kim G Johnson, MD (SUB_INVESTIGATOR)

Find similar trials in Durham, NC

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Duke University· Durham, NC

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