Retinal Imaging in Neurodegenerative Disease

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT03233646
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Retinal and Choroidal Imaging — DEVICE
    Non-invasive OCT, OCTA, and UWF fundus photography of retina

Study Details

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Key Dates

Start date
Jul 20, 2017
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
2,000 participants (estimated)

Arms

  • Arm: Case
    Patients with (MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
  • Arm: Controls
    Controls will be recruited from the relatives/attendants of study participants or will be patients themselves and will not have a neurodegenerative disease diagnosis.

Primary Outcome Measure

Change in ganglion cell-inner plexiform layer (GCIPL) thickness [ Time Frame: Baseline, 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27705
Sharon Fekrat, MD FACS FASRS
[email protected]
919-681-3937

Find similar trials in Durham, NC

By condition
Alzheimer's diseaseHuntington diseaseMultiple sclerosisParkinson's diseasePTSD (post-traumatic stress disorder)
By specialty
NeurologyDementia careBrain disordersGeriatricsAutoimmune diseasePsychiatryMental healthBehavioral health
By research site
Duke University Medical Center· Durham, NC

Related Studies