Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Part of paid clinical trials in Palo Alto, California.

Sponsor
University of Miami
Study ID
NCT02327845
Status
Enrolling By Invitation

Conditions

  • Amyotrophic Lateral Sclerosis
  • Frontotemporal Dementia
  • Hereditary Spastic Paraplegia
  • Multisystem Proteinopathy
  • Primary Lateral Sclerosis
  • Progressive Muscular Atrophy

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Study Details

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Key Dates

Start date
Apr 30, 2015
Status verified
Jul 2025
Primary completion
Jul 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
700 participants (estimated)

Arms

  • Arm: Affected
    Affected with any of the diseases that are the focus of study by the CReATe Consortium, including ALS, ALS-FTD, HSP, PLS, PMA and MSP.
  • Arm: Unaffected
    Unaffected family members of enrolled affected individuals.

Primary Outcome Measure

Phenotypic correlates of genotype [ Time Frame: 24 months ]

Locations (13)

FacilityCityStateZIPSite coordinators
Stanford UniversityPalo AltoCalifornia94304-
University of California San Diego (UCSD)San DiegoCalifornia92093-
California Pacific Medical Center (CPMC)San FranciscoCalifornia94115-
University of MiamiMiamiFlorida33136-
University of IowaIowa CityIowa52242-
Kansas University Medical Center (KUMC)Kansas CityKansas66160-
Twin Cities ALS Research ConsortiumMinneapolisMinnesota55415-
Wake Forest UniversityWinston-SalemNorth Carolina27157-
Cleveland ClinicClevelandOhio44195-
University of PennsylvaniaPhiladelphiaPennsylvania19104-
University of Texas Southwestern (UTSW)DallasTexas75390-
University of Texas Health Science Center San Antonio (UTHSCSA)San AntonioTexas78229-
University of Virginia (UVA)CharlottesvilleVirginia22908-

Find similar trials in Palo Alto, CA

By research site
Stanford University· Palo Alto, CAUniversity of California San Diego (UCSD)· San Diego, CACalifornia Pacific Medical Center (CPMC)· San Francisco, CAUniversity of Miami· Miami, FLUniversity of Iowa· Iowa City, IAKansas University Medical Center (KUMC)· Kansas City, KS

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