Paid Clinical Trials in Durham, NC

As of June 2026, 1,084 paid clinical trials are recruiting in Durham, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,084 clinical trials

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

24 locations incl. Paradise Valley

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting

Apply to this trial

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

6 locations incl. San Francisco

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting

Apply to this trial

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

149 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting

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Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for Glioma, Malignant

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT04547777·Phase 1·Recruiting

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Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients

for Adult Spinal Deformity

9 locations incl. Phoenix

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04888104·Recruiting

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G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study

for Total Hip Arthroplasty

6 locations incl. Denver

Sponsor: Zimmer Biomet

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04754087·Recruiting

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Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

for Prostate Cancer

20 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT04787744·Phase 2, Phase 3·Recruiting

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CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting

Apply to this trial

Long Term Follow up of the LTOG Cohort

for Lung Transplant Failure and Rejection

10 locations incl. Birmingham

Sponsor: University of Pennsylvania

Sex: All·Age: 13+

Code: NCT04787822·Enrolling By Invitation

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

for Prostate Cancer

24 locations incl. Tucson

Sponsor: Astellas Pharma Global Development, Inc.

Sex: Male·Age: 18+

Code: NCT04729114·Phase 1·Recruiting

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Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care

for Fractures, Bone

4 locations incl. Orlando

Sponsor: LifeNet Health

Sex: All·Age: All ages

Code: NCT04299022·Recruiting

Apply to this trial

DALY II USA/ MB-CART2019.1 for DLBCL

for Refractory Diffuse Large B Cell Lymphoma (DLBCL)

23 locations incl. Gilbert

Sponsor: Miltenyi Biomedicine GmbH

Sex: All·Age: 18+

Code: NCT04792489·Phase 2·Recruiting

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A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

for Pulmonary Arterial Hypertension

27 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07218029·Phase 3·Recruiting

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Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

for Locally Advanced (Inoperable) or Metastatic Breast Cancer

54 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT04862663·Phase 3·Recruiting

Apply to this trial

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery

for Intrahepatic Cholangiocarcinoma

10 locations incl. Bethesda

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT04891289·Phase 2·Recruiting

Apply to this trial

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

19 locations incl. New Haven

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting

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Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

for Symptomatic Hypertrophic Cardiomyopathy (HCM)

Drug: Aficamten

52 locations incl. Birmingham

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT04848506·Phase 2, Phase 3·Enrolling By Invitation

Exercise and Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT04921917·Recruiting

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LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

for Superficial Bladder Cancer

49 locations incl. Birmingham

Sponsor: enGene, Inc.

Sex: All·Age: 18+

Code: NCT04752722·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

14 locations incl. San Francisco

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting

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Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

for Propionic Acidemia

15 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: All ages

Code: NCT04159103·Phase 1, Phase 2·Recruiting

Apply to this trial

Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx

for Oropharynx Cancer

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04667585·Recruiting

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A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting

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Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature

for Peripheral Vascular Diseases

52 locations incl. Jonesboro

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT04674969·Recruiting

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A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

for Epilepsy

2 locations incl. Hawthorne

Sponsor: UCB Biopharma SRL

Sex: All·Age: 1 Month+

Code: NCT04715646·Phase 3·Recruiting

Apply to this trial

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

for Advanced Solid Tumor Cancer

Drug: ABBV-CLS-484

15 locations incl. Tucson

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18+

Code: NCT04777994·Phase 1·Recruiting

Apply to this trial

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

31 locations incl. Phoenix

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

621 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting

Apply to this trial

Opioid Treatment and Peer Recovery Support

for Opioid-use Disorder

3 locations incl. Durham

Sponsor: Brown University

Sex: All·Age: 18+

Code: NCT04978168·Recruiting

Apply to this trial

Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

for PTCL

6 locations incl. Long Beach

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT04747236·Phase 2·Recruiting

Apply to this trial

PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

10 locations incl. Aurora

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting

Apply to this trial

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

163 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting

Apply to this trial

Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

for Tourniquet Hypertension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04454203·Phase 4·Recruiting

Apply to this trial

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

for Acute Respiratory Distress Syndrome

76 locations incl. Birmingham

Sponsor: University of Michigan

Sex: All·Age: 14 Days - 20

Code: NCT05388708·Recruiting

Apply to this trial

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

for Mitral Regurgitation

2 locations incl. Durham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04761120·Recruiting

Apply to this trial

Aimovig Pregnancy Exposure Registry

for Migraine

1 location in Durham

Sponsor: Amgen

Sex: Female·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06150781·Recruiting

Apply to this trial

Prebiotic Galacto-oligosaccharide and Acute GVHD

for Acute GVHD

2 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 80

Code: NCT04373057·Phase 1, Phase 2·Recruiting

Apply to this trial

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

109 locations incl. Birmingham

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting

Apply to this trial

The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

for Traumatic Brain Injury

10 locations incl. San Diego

Sponsor: University of Michigan

Sex: All·Age: 16 - 65

Code: NCT04855396·Recruiting

Apply to this trial