Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Part of paid clinical trials in Phoenix, Arizona.

Sponsor: Massachusetts General Hospital
Study ID: NCT04916210
Status: Recruiting

Conditions

Dementia, Vascular
Intracerebral Hemorrhage
Ischemic Stroke
Mild Cognitive Impairment
Subarachnoid Hemorrhage
Vascular Cognitive Impairment

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Study Details

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.

Key Dates

Start date: Mar 5, 2021
Status verified: Oct 2025
Primary completion: Aug 31, 2026
Completion: Aug 31, 2026

Study Design

Enrollment: 8,000 participants (estimated)

Primary Outcome Measure

Change in post-stroke cognitive impairment and dementia (PSCID) diagnosis status [ Time Frame: Baseline to 48 months post-index stroke ]

Central Contacts

James Meschia, MD
904-953-6515
[email protected]

Locations (31)

Facility	City	State	ZIP	Site coordinators
Barrow Neurological Institute	Phoenix	Arizona	85013	Supreet Kaur, MD [email protected] Supreet Kaur, MD (PRINCIPAL_INVESTIGATOR)
Cedars Sinai Medical Center	Los Angeles	California	90048	Shlee Song, MD Shlee Song, MD (PRINCIPAL_INVESTIGATOR)
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Navdeep Sangha, MD Pamela Cheng, DO Navdeep Sangha, MD (PRINCIPAL_INVESTIGATOR) Pamela Cheng, DO (PRINCIPAL_INVESTIGATOR)
University of California Los Angeles	Los Angeles	California	90095	Katherine Mun, MD Katherine Mun, MD (PRINCIPAL_INVESTIGATOR)
University of California San Diego	San Diego	California	92037	Brett Meyer, MD Brett Meyer, MD (PRINCIPAL_INVESTIGATOR)
University of Colorado	Denver	Colorado	80045	Jennifer Simpson, MD Jennifer Simpson, MD (PRINCIPAL_INVESTIGATOR)
Mayo Clinic	Jacksonville	Florida	32224	Michelle Lin, MD, MPH Michelle Lin, MD, MPH (PRINCIPAL_INVESTIGATOR)
University of Miami Health System	Miami	Florida	33125	Nicole Sur, MD Nicole Sur, MD (PRINCIPAL_INVESTIGATOR)
The University of Chicago Medical Center	Chicago	Illinois	60637	Karen Orjuela, MD, MS Karen Orjuela, MD, MS (PRINCIPAL_INVESTIGATOR)
Indiana University	Indianapolis	Indiana	46202	Jason Mackey, MD Jason Mackey, MD (PRINCIPAL_INVESTIGATOR)
University of Iowa	Iowa City	Iowa	52242	-
University of Maryland Medical Center	Baltimore	Maryland	21201	Gunjan Parikh, MD Gunjan Parikh, MD (PRINCIPAL_INVESTIGATOR)
Boston Medical Center	Boston	Massachusetts	02118	Hugo Aparicio, MD, MPH Hugo Aparicio, MD, MPH (PRINCIPAL_INVESTIGATOR)
Massachusetts General Hospital	Boston	Massachusetts	02114	Natalia Rost, MD Natalia Rost, MD (PRINCIPAL_INVESTIGATOR)
University of Michigan	Ann Arbor	Michigan	48109	-
University of Minnesota Health	Minneapolis	Minnesota	55455	Kamakshi Lakshminarayan, MD, PhD, MS Kamakshi Lakshminarayan, MD, PhD, MS (PRINCIPAL_INVESTIGATOR)
Mayo Clinic	Rochester	Minnesota	55902	Eugene Scharf, MD Eugene Scharf, MD (PRINCIPAL_INVESTIGATOR)
University of Mississippi Medical Center	Jackson	Mississippi	39216	Shreyas Gangadhara, MD Shreyas Gangadhara, MD (PRINCIPAL_INVESTIGATOR)
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Michael Waters, MD, PhD Michael Waters, MD, PhD (PRINCIPAL_INVESTIGATOR)
Montefiore Medical Center	The Bronx	New York	10467	Daniel Antoniello, MD Daniel Antoniello, MD (PRINCIPAL_INVESTIGATOR)
Duke University Medical Center	Durham	North Carolina	27708	Nada El Husseini, MD, MHS Nada El Husseini, MD, MHS (PRINCIPAL_INVESTIGATOR)
Wake Forest Baptist Health	Winston-Salem	North Carolina	27157	-
University of Cincinnati	Cincinnati	Ohio	45219	Stacie Demel, DO, PhD Stacie Demel, DO, PhD (PRINCIPAL_INVESTIGATOR)
The Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Kelly Sloane, MD Kelly Sloane, MD (PRINCIPAL_INVESTIGATOR)
Methodist University Hospital	Memphis	Tennessee	38104	Balaji Krishnaiah, MD Balaji Krishnaiah, MD (PRINCIPAL_INVESTIGATOR)
Houston Methodist Research Institute	Houston	Texas	77030	Rajan Gadhia, MD Rajan Gadhia, MD (PRINCIPAL_INVESTIGATOR)
UTHealth	Houston	Texas	77030	Sean Savitz, MD Seema Aggarwal, PhD, APRN, AGNP-C Sean Savitz, MD (PRINCIPAL_INVESTIGATOR) Seema Aggarwal, PhD, APRN, AGNP-C (PRINCIPAL_INVESTIGATOR)
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Andrew Slusher, MD Andrew Slusher, MD (PRINCIPAL_INVESTIGATOR)
University of Utah	Salt Lake City	Utah	84132	Jennifer Majersik, MD, MS Jennifer Majersik, MD, MS (PRINCIPAL_INVESTIGATOR)
University of Virginia	Charlottesville	Virginia	22903	Bradford Worrall, MD Bradford Worrall, MD (PRINCIPAL_INVESTIGATOR)
University of Washington, Harborview Medical Center	Seattle	Washington	98104	Rizwan Kalani, MD Rizwan Kalani, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Phoenix, AZ

By condition

Stroke

By specialty

Neurology Brain disorders

By research site

Barrow Neurological Institute· Phoenix, AZ Cedars Sinai Medical Center· Los Angeles, CA Kaiser Permanente Los Angeles Medical Center· Los Angeles, CA University of California Los Angeles· Los Angeles, CA University of California San Diego· San Diego, CA University of Colorado· Denver, CO

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