Clinical Trials at Nationwide Children's Hospital

As of June 2026, 229 paid clinical trials are recruiting at Nationwide Children's Hospital, located at 700 CHILDRENS DR, COLUMBUS, OH 43205-2696, phone (614) 355-2103 in Columbus, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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229 clinical trials at Nationwide Children's Hospital

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Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease

for Adult Congenital Heart Disease

3 locations incl. Washington D.C.

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT06952933·Recruiting

Apply to this trial

Gene Therapy for SLC6A1 Neurodevelopmental Disorder

for SLC6A1

1 location in Columbus

Sponsor: Emily de los Reyes

Sex: All·Age: All ages

Code: NCT07173153·Phase 1, Phase 2·Enrolling By Invitation

Premedication Gastric Ultrasound

for Surgery

1 location in Columbus

Sponsor: Kevin Spellman

Sex: All·Age: 0 - 18

Code: NCT04130022·Enrolling By Invitation

Healthy Children and Virtual Reality Mediation of Simulated Pain

for Acute Pain

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 6 - 17·Accepts healthy volunteers

Code: NCT06854991·Enrolling By Invitation

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting

Apply to this trial

Re-Engaging AYA Survivors in Cancer-Related Healthcare

for Cancer

3 locations incl. Columbus

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 15 - 29

Code: NCT07138040·Recruiting

Apply to this trial

Survivors Journey+

for Pediatric Brain Tumor

2 locations incl. Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 25

Code: NCT07321353·Recruiting

Apply to this trial

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

for Diffuse Intrinsic Pontine Gliomas (DIPG)

12 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT06838676·Phase 2·Recruiting

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

20 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting

Apply to this trial

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

for Angelman Syndrome

15 locations incl. Los Angeles

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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Health Literacy in the Perioperative Setting

for Pediatric Surgery

1 location in Columbus

Sponsor: Brittany Willer

Sex: All·Age: 3 - 17

Code: NCT07138482·Recruiting

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A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

for B Acute Lymphoblastic Leukemia

137 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 366 Days - 46

Code: NCT06124157·Phase 2·Recruiting

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Minima Stent System Post- Approval Study (PAS)

for Pulmonary Artery Stenosis

15 locations incl. Los Angeles

Sponsor: Renata Medical

Sex: All·Age: All ages

Code: NCT06828770·Recruiting

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Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy

for LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)

14 locations incl. Los Angeles

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 5

Code: NCT06503367·Recruiting

Apply to this trial

Digital Literacy in Caregivers of Pediatric Surgery Patients

for Digital Literacy

1 location in Columbus

Sponsor: Brittany Willer

Sex: All·Age: 0 - 18

Code: NCT07060326·Recruiting

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Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

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Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells

for High Grade Glioma

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT04254419·Phase 1·Recruiting

Apply to this trial

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

190 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting

Apply to this trial

Perioperative Sleep Quality and Postoperative Pain Outcomes

for Surgery

1 location in Columbus

Sponsor: Grant Heydinger

Sex: All·Age: 10 - 18

Code: NCT06054802·Enrolling By Invitation

Pediatric Cochlear Implant Remote Programming and Assessment

for Cochlear Implant Listeners

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 13 - 20

Code: NCT07035873·Recruiting

Apply to this trial

GpCRC Pediatric Gastroparesis Registry 2

for Gastroparesis

6 locations incl. Boston

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 8 - 25

Code: NCT05981300·Recruiting

Apply to this trial

Screen Smart: Using Digital Health to Improve HIV Screening and Prevention

for HIV Infections

4 locations incl. Columbus

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 21·Accepts healthy volunteers

Code: NCT06003192·Recruiting

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NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

13 locations incl. Los Angeles

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting

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WBV and Serial Casting for Children With Cerebral Palsy

for Cerebral Palsy (CP)

1 location in Columbus

Sponsor: Ben Reader

Sex: All·Age: 3 - 17

Code: NCT06693388·Recruiting

Apply to this trial

Safer Still (Exploratory Project 3)

for Suicide Prevention

2 locations incl. Columbus

Sponsor: Jeff Bridge

Sex: All·Age: 18 - 90

Code: NCT06558409·Recruiting

Apply to this trial

Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

for Hemorrhagic Shock

23 locations incl. Tucson

Sponsor: Philip Spinella

Sex: All·Age: Up to 17

Code: NCT06070350·Phase 3·Recruiting

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Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients

for Malnutrition, Child

5 locations incl. Atlanta

Sponsor: Fresenius Kabi

Sex: All·Age: 1 Month - 17

Code: NCT06049680·Phase 4·Recruiting

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

92 locations incl. Mobile

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting

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Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy

for DMD-Associated Dilated Cardiomyopathy

3 locations incl. Kansas City

Sponsor: Sardocor Corp.

Sex: Male·Age: 18+

Code: NCT06224660·Phase 1·Recruiting

Apply to this trial

Infant Formula in Infants and Children With Cow's Milk Allergy

for Cow's Milk Allergy

9 locations incl. Phoenix

Sponsor: Abbott Nutrition

Sex: All·Age: 3 Months - 12

Code: NCT06456541·Recruiting

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DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

for Diabetes Mellitus Type 2, Childhood-Onset

20 locations incl. Birmingham

Sponsor: George Washington University

Sex: All·Age: 8 - 15

Code: NCT06525259·Recruiting

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 locations incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting

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A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B

for Hemophilia B

14 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 2+

Code: NCT06379789·Phase 1, Phase 2·Recruiting

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting

Apply to this trial

A Study to Assess Growth in Children With Idiopathic Short Stature

for Idiopathic Short Stature

40 locations incl. Phoenix

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 2 - 16

Code: NCT06309979·Recruiting

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting

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Prospective Home-Based Palliative Care and Hospice Study

for Pediatric Palliative Care

1 location in Columbus

Sponsor: Steven Smith

Sex: All·Age: Up to 19

Code: NCT06362239·Enrolling By Invitation

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

13 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting

Apply to this trial