Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
Dartmouth-Hitchcock Medical Center
Study ID
NCT06952933
Status
Recruiting
Apply to this trial

Conditions

  • Adult Congenital Heart Disease
  • Congenital Heart Disease
  • PTSD

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Other — BEHAVIORAL
    Surveys will be distributed for data collection. A subset of patients will participate in diagnostic clinician interviews. No interventions will be tested.

Study Details

The purpose of this study, entitled "Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample", is to evaluate for exposures during a lifetime with congenital heart disease that may be associated with higher likelihood of developing PTSD. Primary aim: \- Identify individual patient characteristics (medical, psychosocial, socioeconomic, etc.) that are associated with a diagnosis of PTSD. Secondary aims: * Calculate the prevalence of those meeting PTSD criteria in the ACHD population using the "gold standard" diagnostic clinician interview, while using the same data to validate a PTSD screening self-report survey in the ACHD population. * Determine the role of resilience in ACHD patients using a validated screening survey to assess its protective role toward PTSD. Hypotheses: * There are certain exposures (e.g. post-surgical pain, ICU delirium, bullying due to CHD) that are associated with a higher incidence and odds of meeting PTSD criteria. * "Gold standard" diagnostic interviews will most accurately estimate the prevalence of PTSD in ACHD which has been overestimated on prior screening-based studies, although the scope of the problem is still great. * Patients with a higher resilience score will show an association with a lower risk of PTSD.

Key Dates

Start date
Sep 1, 2025
Status verified
Jun 2025
Primary completion
Jun 30, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Overall cohort
    Adults age \>= 18-years with a diagnosis of congenital heart disease. Congenital heart disease will be defined by previously published classification including those listed in the American Heart Association/ American College of Cardiology guidelines for the care of adults with congenital heart disease.

Primary Outcome Measure

PTSD checklist for DSM-5 (PCL-5) [ Time Frame: One-time survey. Distribute to patients during months ~1-2. ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Children's National Medical CenterWashington D.C.District of Columbia20010
Anitha S John, M.D., Ph.D.
[email protected]
202-476-2728
Dartmouth Hitchcock Medical CenterLebanonNew Hampshire03766
David J Harrison, M.D.
[email protected]
603-650-5724
Nationwide Children's HospitalColumbusOhio43205
Jamie Jackson, Ph.D.
[email protected]
614-355-3426

Find similar trials in Washington D.C., DC

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Children's National Medical Center· Washington D.C., DCDartmouth Hitchcock Medical Center· Lebanon, NHNationwide Children's Hospital· Columbus, OH

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