Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

375 clinical trials at Cleveland Clinic

·Clear filters·↓ Download CSV

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

for Dravet Syndrome

31 locations incl. Birmingham

Sponsor: Epygenix

Sex: All·Age: 2+

Code: NCT04462770·Phase 3·Recruiting

Apply to this trial

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

for Myelodysplastic Syndrome

49 locations incl. Birmingham

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04227847·Phase 1·Recruiting

Apply to this trial

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

13 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting

Apply to this trial

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

Apply to this trial

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

for Head and Neck Squamous Cell Carcinoma

15 locations incl. La Jolla

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT04429542·Phase 1·Recruiting

Apply to this trial

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

for Healthy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT05628974·Recruiting

Apply to this trial

Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

20 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting

Apply to this trial

Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL

for CLL/SLL

7 locations incl. Duarte

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 85

Code: NCT04215809·Phase 1·Recruiting

Apply to this trial

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

for Amblyopia

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 6 Months - 90

Code: NCT04310241·Recruiting

Apply to this trial

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL

for Leukemia, Myeloid, Chronic

8 locations incl. Birmingham

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18+

Code: NCT04260022·Phase 1·Recruiting

Apply to this trial

MOON Onsite MRI 10 Years After ACL Reconstruction

for Osteoarthritis, Knee

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 22 - 45·Accepts healthy volunteers

Code: NCT04660955·Enrolling By Invitation

Trifecta-Kidney cfDNA-MMDx Study

for Kidney Transplant Rejection

11 locations incl. Tampa

Sponsor: University of Alberta

Sex: All·Age: All ages

Code: NCT04239703·Recruiting

Apply to this trial

Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)

for Vertebral Artery Stenosis

10 locations incl. Jacksonville

Sponsor: St. Louis University

Sex: All·Age: 18 - 90

Code: NCT03999983·Recruiting

Apply to this trial

Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948·Recruiting

Apply to this trial

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

for Paralysis, Unilateral, Vocal Cord

4 locations incl. Phoenix

Sponsor: APrevent Biotech GmbH

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05119842·Recruiting

Apply to this trial

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

for Stage D Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT04191681·Phase 4·Recruiting

Apply to this trial

RESET System Pivotal Trial (Rev F)

for Diabetes type2

7 locations incl. Washington D.C.

Sponsor: Morphic Medical Inc.

Sex: All·Age: 22 - 65

Code: NCT04101669·Recruiting

Apply to this trial

Kidney Precision Medicine Project

for Acute Kidney Failure

13 locations incl. Tucson

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04334707·Recruiting

Apply to this trial

A Cardiac Disease Quality of Life Study

for Hypertrophic Obstructive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 70

Code: NCT04080492·Recruiting

Apply to this trial

Comparative Imaging Assessment of Valvular Heart Disease

for Valve Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 90

Code: NCT04126018·Recruiting

Apply to this trial

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

42 locations incl. Birmingham

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting

Apply to this trial

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

for Pulmonary Invasive Fungal Infections

32 locations incl. Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days - 21

Code: NCT03827694·Recruiting

Apply to this trial

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for Ewing Sarcoma

23 locations incl. Scottsdale

Sponsor: Inhibrx Biosciences, Inc

Sex: All·Age: 12 - 85

Code: NCT03715933·Phase 1·Recruiting

Apply to this trial

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for Giant Cell Tumor of Bone

14 locations incl. Los Angeles

Sponsor: St. Louis University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03295981·Phase 3·Recruiting

Apply to this trial

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

23 locations incl. La Jolla

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting

Apply to this trial

Gastroschisis Outcomes of Delivery (GOOD) Study

for Gastroschisis

38 locations incl. Phoenix

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT02774746·Recruiting

Apply to this trial

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

for Sarcoma

10 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03244020·Phase 4·Enrolling By Invitation

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

Apply to this trial

CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

27 locations incl. Phoenix

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting

Apply to this trial

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

for Glioblastoma Multiforme

12 locations incl. Los Angeles

Sponsor: Neonc Technologies, Inc.

Sex: All·Age: 18+

Code: NCT02704858·Phase 1, Phase 2·Recruiting

Apply to this trial

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

12 locations incl. Birmingham

Sponsor: Patrick Wen, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting

Apply to this trial

Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

8 locations incl. Los Angeles

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting

Apply to this trial

A Randomized Multicenter Study for Isolated Skin Vasculitis

for Primary Cutaneous Vasculitis

12 locations incl. Kansas City

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02939573·Phase 2·Recruiting

Apply to this trial

VCRC Tissue Repository

for Aortitis

6 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting

Apply to this trial

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

for Non-Small Cell Lung Cancer

40 locations incl. La Jolla

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT02468024·Phase 3·Recruiting

Apply to this trial

Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations

for PTEN

5 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 Months+·Accepts healthy volunteers

Code: NCT02461446·Recruiting

Apply to this trial

Ethanol Induces Skeletal Muscle Autophagy

for Alcoholic Liver Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03209791·Recruiting

Apply to this trial

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

for Amyotrophic Lateral Sclerosis

13 locations incl. Palo Alto

Sponsor: University of Miami

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02327845·Enrolling By Invitation