Ethanol Induces Skeletal Muscle Autophagy

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT03209791
Status
Recruiting
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Conditions

  • Alcoholic Liver Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Biopsies — OTHER
    Biopsy will be done on the Vastus Lateralis muscle in all groups

Study Details

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Key Dates

Start date
May 18, 2015
Status verified
Jan 2026
Primary completion
Jun 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Alcoholic Steatosis
    This group will have 10 patients with alcoholic steatosis which is milder disease and muscle biopsies will be performed
  • Arm: Cirrhosis
    This group will consist of 10 patients with cirrhosis. We anticipate a 50% difference in these patients and the controls in the autophagy readouts and muscle biopsies will be performed
  • Arm: Steatohepatitis
    This group will have 10 patients with alcoholic steatohepatitis that have more severe necroinflammation in the liver but for a shorter duration of illness and muscle biopsies will be performed
  • Arm: controls
    This group will consist of 10 patients who are healthy and have no liver disease diagnosis and muscle biopsies will be performed

Primary Outcome Measure

Skeletal Muscle Autophagy [ Time Frame: 4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195
Revathi Penumatsa
[email protected]
216-445-0688
Annette Bellar
[email protected]
2166365247

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