Clinical Trials at Rush University Medical Center

As of June 2026, 165 paid clinical trials are recruiting at Rush University Medical Center, located at 1725 W HARRISON ST, NUMBER 1118 UNIVERSITY NEUROLOGISTS, CHICAGO, IL 60612-3841, phone (312) 942-5936 in Chicago, Illinois. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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165 clinical trials at Rush University Medical Center

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Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM

for Epiretinal Membrane

45 locations incl. Scottsdale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 50+

Code: NCT05145491·Recruiting

Apply to this trial

InSpace Accelerated Rehabilitation Study

for Rotator Cuff Tears

11 locations incl. Phoenix

Sponsor: Stryker Endoscopy

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT05329584·Recruiting

Apply to this trial

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

for Lumbar Spinal Stenosis

1 location in Chicago

Sponsor: John O'Toole

Sex: All·Age: 18 - 80

Code: NCT05029726·Phase 4·Recruiting

Apply to this trial

HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome

for Angelman Syndrome

6 locations incl. San Diego

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 0 - 50

Code: NCT05127226·Phase 1, Phase 2·Recruiting

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(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

for Advanced Systemic Mastocytosis (AdvSM)

14 locations incl. Birmingham

Sponsor: Cogent Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04996875·Phase 2·Recruiting

Apply to this trial

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

65 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting

Apply to this trial

Study in Parkinson Disease of Exercise

for Parkinson Disease

24 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT04284436·Recruiting

Apply to this trial

Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial

for Lung Cancer

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT04954625·Enrolling By Invitation

Trial of Therapeutic Hypothermia in Patients With ARDS

for Respiratory Distress Syndrome, Adult

19 locations incl. Los Angeles

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 85

Code: NCT04545424·Phase 2·Recruiting

Apply to this trial

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

for Metastatic Non Small Cell Lung Cancer

46 locations incl. Gilbert

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT04614103·Phase 2·Recruiting

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LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

for Superficial Bladder Cancer

49 locations incl. Birmingham

Sponsor: enGene, Inc.

Sex: All·Age: 18+

Code: NCT04752722·Phase 1, Phase 2·Recruiting

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

387 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting

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Fenofibrate for Prevention of DR Worsening

for Diabetic Retinopathy

66 locations incl. Glendale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18 - 80

Code: NCT04661358·Phase 3·Recruiting

Apply to this trial

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

109 locations incl. Birmingham

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting

Apply to this trial

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

for Atrial Fibrillation

4 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 100

Code: NCT02347111·Phase 4·Recruiting

Apply to this trial

Adherus™ Dural Sealant in Spinal Procedures

for Spinal Duraplasty

14 locations incl. Duarte

Sponsor: Stryker Craniomaxillofacial

Sex: All·Age: 18 - 75

Code: NCT04498026·Enrolling By Invitation

The ENCIRCLE Trial

for Mitral Regurgitation

56 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04153292·Recruiting

Apply to this trial

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

20 locations incl. Burbank

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting

Apply to this trial

Hip Arthroscopy Postoperative Opioid Demands

for Opioid Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04094701·Recruiting

Apply to this trial

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

for Hematologic Disorder

71 locations incl. Phoenix

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT04398628·Recruiting

Apply to this trial

NeuroVision vs Standard Neuromonitoring

for Neurologic Deficits

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04639297·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Non-Invasive Quantification of Liver Health in NASH (N-QUAN)

for NASH - Nonalcoholic Steatohepatitis

7 locations incl. Chandler

Sponsor: Perspectum

Sex: All·Age: 18 - 75

Code: NCT04054310·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

for Movement Disorders

23 locations incl. Tucson

Sponsor: Abbott Medical Devices

Sex: All·Age: All ages

Code: NCT04071847·Recruiting

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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery

for Open Posterior Thoracolumbar Spinal Fusion Procedure

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT03849443·EARLY_Phase 1·Recruiting

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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

for Stroke

45 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 70

Code: NCT03821129·Recruiting

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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

for Chronic Pain

30 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT03876054·Recruiting

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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

for Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7

140 locations incl. Tucson

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03493425·Phase 2·Recruiting

Apply to this trial

Study of Individuals Affected With Hypoplasminogenemia

for Plasminogen Deficiency

13 locations incl. Birmingham

Sponsor: Indiana Hemophilia &Thrombosis Center, Inc.

Sex: All·Age: All ages

Code: NCT03797495·Recruiting

Apply to this trial

The Course of Hip Flexion Weakness Following LLIF or ALIF

for Degenerative Disc Disease

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: Up to 65

Code: NCT04204135·Enrolling By Invitation

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

334 locations incl. Gilbert

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting

Apply to this trial

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

for Melanoma Stage IIIB

19 locations incl. Phoenix

Sponsor: Philogen S.p.A.

Sex: All·Age: 18+

Code: NCT03567889·Phase 3·Recruiting

Apply to this trial

Advanced Materials Science in XLIF Study

for Degenerative Disc Disease

15 locations incl. Hartford

Sponsor: NuVasive

Sex: All·Age: 18 - 80

Code: NCT03649490·Enrolling By Invitation

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

Apply to this trial

Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors

for End Stage Renal Disease

6 locations incl. San Diego

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03803423·Recruiting

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Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction

for Anterior Cruciate Ligament Injury

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 60

Code: NCT04650568·Enrolling By Invitation

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

for Mitral Valve Regurgitation

78 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18+

Code: NCT03242642·Recruiting

Apply to this trial

PARTNER 3 Trial - Aortic Valve-in-Valve

for Aortic Stenosis

50 locations incl. Phoenix

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT03003299·Recruiting

Apply to this trial