Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Illinois at Chicago
Study ID
NCT02347111
Phase
PHASE4
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Flecainide — DRUG
    flecainide up to 150mg twice daily for the control of atrial fibrillation
  • Sotalol — DRUG
    sotalol up to 120mg twice daily for the control of atrial fibrillation

Study Details

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will test the hypothesis that a common AF genetic risk allele modulates response to different AADs.

Key Dates

Start date
Dec 31, 2020
Status verified
Aug 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
162 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: flecainide 1st
    flecainide x 6 months, then crossover to sotalol x 6 months
  • Experimental: sotalol 1st
    sotalol x 6 months, then crossover to flecainide x 6 months

Primary Outcome Measure

AF burden (Percent of time subject is in atrial fibrillation) [ Time Frame: 12 months ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Jesse Brown VA Medical CenterChicagoIllinois60612
Sorin Lazar, MD
[email protected]
312-996-6730
Sorin Lazar, MD (PRINCIPAL_INVESTIGATOR)
Rush University Medical CenterChicagoIllinois60612
Henry Huang, MD
[email protected]
Henry Huang, MD (PRINCIPAL_INVESTIGATOR)
University of Illinois at ChicagoChicagoIllinois60612
Dawood J Darbar, M.D.
[email protected]
6158879032
Dawood Darbar, M.D. (PRINCIPAL_INVESTIGATOR)
Advocate Christ Medical CenterOak LawnIllinois60453
Adarsh Bhan, MD
[email protected]
Adarsh Bhan, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chicago, IL

By condition
Atrial fibrillation
By specialty
CardiologyHeart disease
By research site
Jesse Brown VA Medical Center· Chicago, ILRush University Medical Center· Chicago, ILUniversity of Illinois at Chicago· Chicago, ILAdvocate Christ Medical Center· Oak Lawn, IL

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