Clinical Trials at University of North Carolina at Chapel Hill

As of June 2026, 148 paid clinical trials are recruiting at University of North Carolina at Chapel Hill, located at 101 MANNING DR, CHAPEL HILL, NC 27514-4220, phone (919) 966-4676 in Chapel Hill, North Carolina. Active studies at this site cover conditions such as Breast Cancer, Multiple Myeloma and Obesity. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

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148 clinical trials at University of North Carolina at Chapel Hill

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Marine Lipids Ease Painful TMD

for Temporomandibular Disorder (TMD)
1 location in Chapel Hill
Sponsor: University of North Carolina, Chapel Hill
Sex: All·Age: 18+
Code: NCT07437313·Not Yet Recruiting

Caring for the Carer

for Care Burden
1 location in Chapel Hill
Sponsor: University of North Carolina, Chapel Hill
Sex: All·Age: 18 - 99·Accepts healthy volunteers
Code: NCT07167641·Recruiting
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About research studies in Chapel Hill

Chapel Hill has approximately 729 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.

Common conditions studied in Chapel Hill

  • Breast Cancer (31 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
  • Multiple Myeloma (16 active studies). Recruiting Multiple Myeloma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Cancer (15 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Obesity (11 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
  • Ulcerative Colitis (10 active studies). Ulcerative colitis trials examine biologic therapies, S1P receptor modulators, and oral small molecules for steroid-sparing remission.
  • Acute Myeloid Leukemia (9 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.

Leading research sponsors in Chapel Hill

  • University of North Carolina, Chapel Hill
  • UNC Lineberger Comprehensive Cancer Center
  • National Cancer Institute (NCI)
  • Children's Oncology Group
  • AstraZeneca

Local regulations and guidelines

Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.

Compensation & what to expect

How payment typically works
Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
Healthy volunteers
Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Chapel Hill. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
What's included beyond payment
Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
Travel and time
Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
Asking about compensation
Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.

How to find a clinical trial in Chapel Hill

Hipa.ai aggregates every recruiting study in Chapel Hill from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.

Frequently asked questions

How many paid clinical trials are currently recruiting in Chapel Hill?

There are approximately 729 recruiting clinical trials in Chapel Hill, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Chapel Hill pay participants?

Most recruiting trials in Chapel Hill compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Chapel Hill?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Chapel Hill?

The most common conditions under active study in Chapel Hill include Breast Cancer (31), Multiple Myeloma (16), Cancer (15), Obesity (11), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Chapel Hill?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chapel Hill on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Chapel Hill?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Where can I take part in paid clinical trials in Chapel Hill?

Recruiting research sites in Chapel Hill include University of North Carolina at Chapel Hill, University of North Carolina, UNC Lineberger Comprehensive Cancer Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.

What kinds of studies are recruiting in Chapel Hill right now?

The largest active categories in Chapel Hill are Cancer & tumors (249), Diabetes & metabolic (43), Cardiovascular (29). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.

What is the address of University of North Carolina at Chapel Hill?

University of North Carolina at Chapel Hill is located at 101 MANNING DR, CHAPEL HILL, NC 27514-4220. Use the Google Maps link in the intro above to get directions.

How do I contact University of North Carolina at Chapel Hill?

You can reach University of North Carolina at Chapel Hill by phone at (919) 966-4676. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.

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Related healthcare resources in North Carolina

Latest Chapel Hill, NC clinical trials research report

Trials by condition in Chapel Hill

Breast Cancer· 31Multiple Myeloma· 16Obesity· 11Ulcerative Colitis· 10Acute Myeloid Leukemia· 9Lung Cancer· 9