Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

for Advanced Solid Tumor

Drug: Tulmimetostat

17 locations incl. Atlanta

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04104776·Phase 1, Phase 2·Recruiting

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A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Drug: Cemiplimab

21 locations incl. Gilbert

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT03972657·Phase 1, Phase 2·Recruiting

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

42 locations incl. Birmingham

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting

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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

for Stroke

45 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 70

Code: NCT03821129·Recruiting

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VE416 for Treatment of Food Allergy

for Peanut Allergy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 55

Code: NCT03936998·Phase 1, Phase 2·Recruiting

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

6 locations incl. Duarte

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting

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ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

for Refractory Cancer

Drug: Nivolumab

13 locations incl. Stanford

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT03686124·Phase 1, Phase 2·Recruiting

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Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease

for Parkinson Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 85

Code: NCT04566341·Enrolling By Invitation

A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception

for Amputation

4 locations incl. Bethesda

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03882073·Recruiting

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Developing Fast Pediatric Imaging

for Pediatric Low-grade Gliomas

3 locations incl. Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT03761121·Recruiting

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Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

for Leukemia, Myeloid, Acute

Drug: Tuspetinib

15 locations incl. Birmingham

Sponsor: Aptose Biosciences Inc.

Sex: All·Age: 18+

Code: NCT03850574·Phase 1, Phase 2·Recruiting

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EVOC - EVs in Obesity and Cardiometabolic Disease

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06408961·Recruiting

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Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04561791·Enrolling By Invitation

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

37 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting

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Vagal Nerve Stimulation for Functional Dyspepsia and Gastroparesis

for Dyspepsia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT03603730·Recruiting

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Medtronic Terminate AF Study

for Persistent Atrial Fibrillation

15 locations incl. Palo Alto

Sponsor: Medtronic Cardiac Surgery

Sex: All·Age: 18+

Code: NCT03546374·Recruiting

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Endovascular Treatment of Thoracic Aortic Disease

for Thoracic Aortic Aneurysms

2 locations incl. Boston

Sponsor: Matthew Eagleton

Sex: All·Age: 18+

Code: NCT00583817·Enrolling By Invitation

Developing Viability Index for Machine Perfused Livers

for Liver Cirrhoses

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT03694691·Recruiting

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Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

for Brain Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03286335·Recruiting

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Imaging Histone Deacetylase in the Heart

for Heart Failure With Normal Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT03549559·Recruiting

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Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

for Ascending Aortic Aneurysm Enlargement

15 locations incl. San Francisco

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18 - 79

Code: NCT03536312·Recruiting

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Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT04496947·Recruiting

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North American Prodromal Synucleinopathy Consortium

for REM Sleep Behavior Disorder

9 locations incl. Sun City

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT03623672·Enrolling By Invitation

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

65 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting

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NLP to Aid in the Evaluation and Diagnosis of FGIDs

for Functional Gastrointestinal Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05501028·Enrolling By Invitation

Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03535545·Phase 1·Recruiting

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Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

for Recurrent Ovarian Cancer

Drug: Cemiplimab

11 locations incl. Birmingham

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT03564340·Phase 1, Phase 2·Recruiting

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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for Giant Cell Tumor of Bone

14 locations incl. Los Angeles

Sponsor: St. Louis University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03295981·Phase 3·Recruiting

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Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Brain Connectivity in Depression

for Depression

4 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03276793·Recruiting

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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

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Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03830801·Recruiting

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Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

for Leukemia, Lymphocytic, Chronic, B-Cell

84 locations incl. Birmingham

Sponsor: Juno Therapeutics, a Subsidiary of Celgene

Sex: All·Age: 18+

Code: NCT03331198·Phase 1, Phase 2·Recruiting

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Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

for Mitral Valve Regurgitation

78 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18+

Code: NCT03242642·Recruiting

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Genes and Environment in Multiple Sclerosis

for Multiple Sclerosis

5 locations incl. Bethesda

Sponsor: Columbia University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01353547·Recruiting

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OCT Guided Trans Nasal Imaging of the Small Intestine in Adults

for Environmental Enteric Dysfunction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT04984447·Enrolling By Invitation

Turmeric for Patients With Basal Joint Arthritis

for Thumb Osteoarthritis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40+

Code: NCT03017118·Recruiting

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Stroke Motor Rehabilitation and Recovery Study

for Stroke, Ischemic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT03485040·Recruiting

Apply to this trial