Genes and Environment in Multiple Sclerosis

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
Columbia University
Study ID
NCT01353547
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Key Dates

Start date
Oct 1, 2017
Status verified
May 2026
Primary completion
Oct 31, 2040
Completion
Oct 31, 2040

Study Design

Enrollment
5,000 participants (estimated)

Arms

  • Arm: Received anti-TNFa therapy
    Received anti-TNFa therapy
  • Arm: First-degree relative of MS patients
    First-degree relative (child, parent or sibling) of a diagnosed MS patient A subgroup will be asked to undergo magnetic resonance imaging (MRI). Participants may be asked to donate a stool sample for gut flora analysis and a blood sample for ribonucleic acid (RNA) sequencing.
  • Arm: Referred by the Partners MS Center
    Referred by the Partners MS Center

Primary Outcome Measure

Total number of subjects who are diagnosed with MS [ Time Frame: 20 years ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
National Institute of Neurological Disorders and StrokeBethesdaMaryland15213
Daniel S Reich, MD, PhD (PRINCIPAL_INVESTIGATOR)
Brigham and Women's HospitalBostonMassachusetts02115-
Massachusetts General HospitalBostonMassachusetts02114-
Columbia University Irving CenterNew YorkNew York10032
Juliana Oyegunle
[email protected]
212-305-2434
Philip L De Jager, MD, PhD (PRINCIPAL_INVESTIGATOR)
University of PittsburghPittsburghPennsylvania15213
Zongqi Xia, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Bethesda, MD

By condition
Multiple sclerosis
By specialty
NeurologyBrain disordersAutoimmune disease
By research site
National Institute of Neurological Disorders and Stroke· Bethesda, MDBrigham and Women's Hospital· Boston, MAMassachusetts General Hospital· Boston, MAColumbia University Irving Center· New York, NYUniversity of Pittsburgh· Pittsburgh, PA

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