EVOC - EVs in Obesity and Cardiometabolic Disease

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT06408961
Status
Recruiting
Apply to this trial

Conditions

  • Cardiovascular Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, the focus is on the content and function of Extracellular Vesicles (EVs), small sacs released from a cell's surface that contain important molecular cargo. The main questions it aims to answer are: 1. What molecular cargo do adipose-tissue EVs carry? 2. How do these cargo impact cardiac and hepatic function? 3. Are changes in EV content related to cardiac function and adiposity with weight loss? Tissue samples from fat tissue and blood samples will be collected from patients receiving bariatric weight loss surgery.

Key Dates

Start date
Feb 2, 2019
Status verified
Nov 2025
Primary completion
May 1, 2026
Completion
May 30, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Bariatric Surgery
    Patients undergoing bariatric surgery

Primary Outcome Measure

What are the contents inside of fat (adipose) tissue derived Extracellular Vesicles (EVs)? [ Time Frame: 2 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114-2696
Clinical Research Coordinator
[email protected]
617-643-9621
Saumya Das, MD/PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By research site
Massachusetts General Hospital· Boston, MA

Related Studies