Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities

for RET-altered Non Small Cell Lung Cancer

9 locations incl. Orange

Sponsor: Taiho Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT04683250·Phase 1, Phase 2·Recruiting

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A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

13 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting

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Extracellular RNA Biomarkers of Myotonic Dystrophy

for Myotonic Dystrophy

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05020002·Recruiting

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The ENCIRCLE Trial

for Mitral Regurgitation

56 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04153292·Recruiting

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

32 locations incl. Irvine

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting

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Thoracoabdominal Asynchrony and Respiratory Distress

for Respiratory Insufficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 28 Days - 17

Code: NCT04626154·Recruiting

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Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

for Early-stage Breast Cancer

9 locations incl. Fullerton

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04553770·Phase 2·Recruiting

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The BENeFiTS Trial in Beta Thalassemia Intermedia

for Beta Thalassemia Intermedia

4 locations incl. Oakland

Sponsor: Phoenicia BioScience

Sex: All·Age: 18+

Code: NCT04432623·Phase 1, Phase 2·Enrolling By Invitation

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

for Transthyretin Amyloidosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT05577819·Recruiting

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Cortical-Basal Ganglia Speech Networks

for Parkinson Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT04286308·Recruiting

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting

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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

6 locations incl. Gilbert

Sponsor: ImmVira Pharma Co. Ltd

Sex: All·Age: 18+

Code: NCT04370587·Phase 1, Phase 2·Recruiting

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Decompression Versus Decompression and Fusion

for Adjacent Segment Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04542720·Recruiting

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A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

for Myelodysplastic Syndrome

49 locations incl. Birmingham

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04227847·Phase 1·Recruiting

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Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

13 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting

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Buspirone and Melatonin for Depression Following Traumatic Brain Injury

for Depression

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64

Code: NCT04400266·Phase 4·Recruiting

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Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT04485286·Phase 2·Recruiting

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Sacituzumab Govitecan In TNBC

for Invasive Breast Cancer

5 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04230109·Phase 2·Recruiting

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting

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The HALT Biomarker Study

for Aortic Stenosis

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT04552275·Phase 1·Recruiting

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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

for Neurofibromatosis Type 2

6 locations incl. Los Angeles

Sponsor: Scott R. Plotkin, MD, PhD

Sex: All·Age: 12+

Code: NCT04374305·Phase 2·Recruiting

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HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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A Study of Sigvotatug Vedotin in Advanced Solid Tumors

for Carcinoma, Non-Small Cell Lung

Drug: sigvotatug vedotin

105 locations incl. Anchorage

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04389632·Phase 1·Recruiting

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Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

for Prostate Carcinoma

8 locations incl. Duarte

Sponsor: University of Washington

Sex: Male·Age: 40+·Accepts healthy volunteers

Code: NCT04472338·Recruiting

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Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

for Metastatic Colon Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03803553·Phase 3·Recruiting

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Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer

for Ovarian Neoplasms

6 locations incl. Little Rock

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 30+

Code: NCT04794322·Recruiting

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CERAMENT™| Bone Void Filler Device Registry

for Orthopedic Disorder

13 locations incl. Scottsdale

Sponsor: BONESUPPORT AB

Sex: All·Age: 18+

Code: NCT04244942·Recruiting

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting

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Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

Prostate Cancer Genetic Risk Evaluation and Screening Study

for Prostatic Neoplasm

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 35 - 74

Code: NCT05129605·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

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KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for Carcinoma, Non-Small-Cell Lung

18 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165070·Phase 1, Phase 2·Recruiting

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KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for Carcinoma, Non-Small-Cell Lung

18 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165798·Recruiting

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A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

for Myelofibrosis

32 locations incl. Birmingham

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT04176198·Phase 1, Phase 2·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

for Tricuspid Regurgitation

73 locations incl. Phoenix

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04097145·Recruiting

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Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy

for Duchenne Muscular Dystrophy

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+

Code: NCT05016908·Recruiting

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Effect of Theophylline in Pseudohypoparathyroidism

for PHP Ia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5 - 21

Code: NCT03718403·Phase 4·Recruiting

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A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia

for Warm Antibody Autoimmune Hemolytic Anemia

Drug: Fostamatinib

8 locations incl. Los Angeles

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT04138927·Phase 3·Enrolling By Invitation

Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab

for Solid Tumor, Adult

10 locations incl. Los Angeles

Sponsor: Linnaeus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT04130516·Phase 1, Phase 2·Recruiting

Apply to this trial