ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Mayo Clinic
Study ID
NCT04363684
Status
Recruiting
Apply to this trial

Conditions

  • Amyotrophic Lateral Sclerosis
  • Behavioral Variant Frontotemporal Dementia (bvFTD)
  • C9orf72
  • Corticobasal Degeneration (CBD)
  • FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)
  • Frontotemporal Lobar Degeneration (FTLD)
  • GRN Related Frontotemporal Dementia
  • MAPT Gene Mutation
  • Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
  • Oligosymptomatic PSP (oPSP)
  • Oligosymptomatic Progressive Supranuclear Palsy
  • Progressive Supranuclear Palsy (PSP)
  • Semantic Variant Primary Progressive Aphasia (svPPA)
  • TBK1 Gene Mutation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

Key Dates

Start date
Mar 1, 2020
Status verified
Jul 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
2,100 participants (estimated)

Arms

  • Arm: Longitudinal Arm
    Annual clinic visits throughout the length of the study.
  • Arm: Biofluid-Focused Arm
    Single clinic visit.

Primary Outcome Measure

Change in Brain Volumes [ Time Frame: Baseline, 1 Year, 2 Year, 3 Year, 4 Year, 5 Year ]

Central Contacts

Locations (25)

FacilityCityStateZIPSite coordinators
University of Alabama BirminghamBirminghamAlabama35233
Erik Roberson, MD (PRINCIPAL_INVESTIGATOR)
University of California, Los AngelesLos AngelesCalifornia90095
Alexander Sheppard
[email protected]
Mario Mendez, MD (PRINCIPAL_INVESTIGATOR)
University of California, San DiegoSan DiegoCalifornia92093
Michael Skipworth
[email protected]
Brandon Pulido
[email protected]
Irene Litvan, MD (PRINCIPAL_INVESTIGATOR)
Doug Galasko, MD (PRINCIPAL_INVESTIGATOR)
Gabriel Leger, MD (PRINCIPAL_INVESTIGATOR)
University of California San FranciscoSan FranciscoCalifornia91358
Cole Mollard
[email protected]
Adam Boxer, MD, Ph.D (PRINCIPAL_INVESTIGATOR)
Howard Rosen, MD (PRINCIPAL_INVESTIGATOR)
University of Colorado DenverDenverColorado80204
Danelle Carter
[email protected]
Ece Bayram, MD (PRINCIPAL_INVESTIGATOR)
Mayo Clinic FloridaJacksonvilleFlorida32224
Kandise Chrestensen
[email protected]
Neill Graff-Radford, MD (PRINCIPAL_INVESTIGATOR)
Emory UniversityAtlantaGeorgia30322
Samantha Heldenberg
[email protected]
Chad Hales, MD (PRINCIPAL_INVESTIGATOR)
Northwestern UniversityChicagoIllinois60611
Northwestern Study Team
[email protected]
Ian Grant, MD (PRINCIPAL_INVESTIGATOR)
Sandra Weintraub, PhD (PRINCIPAL_INVESTIGATOR)
Indiana UniversityIndianapolisIndiana46202
Ralitsa Kostadinova
[email protected]
David Clark, MD (PRINCIPAL_INVESTIGATOR)
Johns Hopkins UniversityBaltimoreMaryland21287
Chiadi Onyike, MD, MHS (PRINCIPAL_INVESTIGATOR)
NIHBethesdaMaryland20814
Carol Hoffman
[email protected]
Allison Snyder, MD (PRINCIPAL_INVESTIGATOR)
Justin Kwan, MD (PRINCIPAL_INVESTIGATOR)
Massachusetts General HospitalBostonMassachusetts02114
Brad Dickerson, MD (PRINCIPAL_INVESTIGATOR)
University of MichiganAnn ArborMichigan48109
Kiren Chaudhry
[email protected]
Sami Barmada, MD (PRINCIPAL_INVESTIGATOR)
Mayo Clinic RochesterRochesterMinnesota55905
Abbi Osborne
[email protected]
Bradley Boeve, MD (PRINCIPAL_INVESTIGATOR)
Washinton University in St. LouisSt LouisMissouri63110
Nupur Ghoshal, MD, PhD (PRINCIPAL_INVESTIGATOR)
Cleveland Clinic Lou Ruvo Center for Brain HealthLas VegasNevada89106
Ghanen Concepcion
[email protected]
Dylan Wint, MD (PRINCIPAL_INVESTIGATOR)
Columbia UniversityNew YorkNew York10032
Arlene Mejia
[email protected]
Lawrence S Honig, MD (PRINCIPAL_INVESTIGATOR)
Mount SinaiNew YorkNew York10029
Anna Torten Rabinowitz
[email protected]
Fanny Elahi (PRINCIPAL_INVESTIGATOR)
University of North Carolina, Chapel HillChapel HillNorth Carolina27514
UNC ALLFTD Team
[email protected]
Andrea Bozoki, MD (PRINCIPAL_INVESTIGATOR)
Case Western Reserve Medical CenterClevelandOhio44106
Brain Appleby, MD (PRINCIPAL_INVESTIGATOR)
University of PennsylvaniaPhiladelphiaPennsylvania19104
Jessica Legaspi
[email protected]
David Irwin, MD (PRINCIPAL_INVESTIGATOR)
Vanderbilt UniversityNashvilleTennessee37235
Jerica Braswell
[email protected]
Richard R Darby, MD (PRINCIPAL_INVESTIGATOR)
Nantz National Alzheimer Center HoustonHoustonTexas77030
Victoria Arbones
[email protected]
Belen Pascual, PhD (PRINCIPAL_INVESTIGATOR)
Joseph Masdeu, MD, PhD (PRINCIPAL_INVESTIGATOR)
UT San Antonio Health Science CenterSan AntonioTexas78229
Crystal Mendoza
[email protected]
A.Campbell Sullivan, PsyD, ABPP (PRINCIPAL_INVESTIGATOR)
University of WashingtonSeattleWashington98195
Alicia Adams
[email protected]
Kimiko Domoto-Reilly, MD (PRINCIPAL_INVESTIGATOR)

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