Teenthrive 2: Treatments for Improving Mood in Teens

Conditions

• Depression in Adolescence

Eligibility Criteria

Sex

ALL

Age

12 Years - 18 Years

Healthy Volunteers

Not accepted

Interventions

• Yoga-Based Intervention — BEHAVIORAL
  This intervention consists of twice-weekly yoga classes. Classes will be led by trained yoga teachers. Each week for 12 weeks, classes will occur once in person (55 mins) and once virtually (30 mins).
• group CBT — BEHAVIORAL
  This intervention consists of twice-weekly group CBT sessions. Sessions will be led by trained behavioral health specialists. Each week for 12 weeks, sessions will occur once in person (55 mins) and once virtually (30 mins).

Study Details

In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, OH and Boston, MA (96 total). We have a priori targets for indices of feasibility and acceptability, including recruitment rate, retention for assessments, class attendance, interventionist fidelity to manuals, and participant satisfaction. We hypothesize that we will meet these metrics at both sites.

Key Dates

Start date

Jun 15, 2026

Status verified

Jun 2026

Primary completion

Dec 31, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

96 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Experimental: Yoga arm
  Yoga-based intervention
• Active Comparator: gCBT arm
  group CBT

Primary Outcome Measure

Credibility [ Time Frame: Start of treatment ]

Central Contacts

• Bailey O'Keeffe, MA
  401-455-6219
  [email protected]
• Julie Desaulniers
  401-455-6219
  [email protected]

Locations (2)

Find similar trials in Boston, MA

Related Studies

• Mindfulness-Based fMRI Neurofeedback for Depression
  Recruiting · Columbia University · Boston, Massachusetts
• Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
  Recruiting · University of California, Los Angeles · Los Angeles, California
• Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
  Recruiting · University of Alabama at Birmingham · Birmingham, Alabama
• Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
  Recruiting · University of Oregon · Eugene, Oregon