Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT05329441
Status
Recruiting
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Conditions

  • Depression in Adolescence

Eligibility Criteria

Sex
ALL
Age
14 Years - 21 Years
Healthy Volunteers
Not accepted

Interventions

  • Trier Social Stress Test (TSST) — BEHAVIORAL
    In this mechanistic study, all participants will undergo a modified version of the Trier Social Stress Test (TSST), which is a well-validated psychosocial stress paradigm, adapted for adolescents that involves no deception and is considered a very mild stressor. The TSST comprises of two stress tests: a 5-minute arithmetic task and a 5-minute speech task. Due to repeated testing of the TSST, participants will be randomized to one task at T1 and complete the second task at T2 (counterbalanced design). Every 5 minutes, participants will provide ratings of their mood using a visual analogue scale (1-10) of eight mood states (Afraid, Confused, Sad, Angry, Energetic, Tired, Happy, and Tense) that will be used as potential behavioral responses to social stress. Glutamate and inflammation outcomes will be examined acutely and from T1 and T2.

Study Details

Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstream levels of glutamate in corticolimbic regions previously associated with depression, whether these stress-related biomarkers predict TNR to a 12-week trial of either fluoxetine or escitalopram, and whether these stress-related biomarkers predict 18-month clinical course.

Key Dates

Start date
Jul 6, 2023
Status verified
May 2026
Primary completion
Apr 1, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: Study Participants
    All depressed participants will undergo the same study procedures

Primary Outcome Measure

Children's Depressing Rating Scale-Revised [ Time Frame: baseline and 12-week follow-up ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095
Tiffany Ho, Ph.D.
310-825-0561
Tiffany C Ho, Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
University of California, Los Angeles· Los Angeles, CA

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