Mindfulness-Based fMRI Neurofeedback for Depression

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Columbia University
Study ID
NCT05617495
Status
Recruiting
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Conditions

  • Depression in Adolescence
  • Rumination

Eligibility Criteria

Sex
ALL
Age
13 Years - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Mindfulness + fMRI Neurofeedback — OTHER
    Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.

Study Details

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.

Key Dates

Start date
Apr 10, 2024
Status verified
Apr 2026
Primary completion
Jan 31, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: 15-Minute mbNF
    Participants receiving mindfulness training and 15-minute session of mbNF
  • Active Comparator: 30-Minute mbNF
    Participants receiving mindfulness training and 30-minute session of mbNF

Primary Outcome Measure

Within-person Default Mode Network (DMN) Connectivity [ Time Frame: Pre-mbNF procedure ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Northeastern UniversityBostonMassachusetts02115
Susan Whitfield-Gabrieli, PhD
[email protected]
Susan Whitfield-Gabrieli, PhD (PRINCIPAL_INVESTIGATOR)
Columbia University Irving Medical CenterNew YorkNew York10032
Randy P Auerbach, PhD
[email protected]
646-774-5745
Randy P Auerbach
Randy Auerbach, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Northeastern University· Boston, MAColumbia University Irving Medical Center· New York, NY

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