Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- University of Alabama at Birmingham
- Study ID
- NCT05437588
- Status
- Recruiting
Conditions
- Depression
- Depression and Suicide
- Depression in Adolescence
- Depression, Teen
- MDD
- Major Depressive Disorder
- Suicidal Ideas
- Suicide
- Suicide, Attempted
Eligibility Criteria
- Sex
- ALL
- Age
- 10 Years - 24 Years
- Healthy Volunteers
- Accepted
Interventions
- Genetic testing — GENETICAttempting to identify the genetic biomarker that can identify risk for suicidal ideation and action
Study Details
This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.
Key Dates
- Start date
- Oct 1, 2022
- Status verified
- Jul 2025
- Primary completion
- Jun 29, 2027
- Completion
- Jun 30, 2027
Study Design
- Enrollment
- 240 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- PREVENTION
Arms
- Other: MDD ParticipantParticipants with MDD will return at six weeks for a second blood draw and assessments
Primary Outcome Measure
Clinical phenotype analysis [ Time Frame: 6 Weeks ]
Central Contacts
- Allison Stewart, MA256-551-4431
Locations (2)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | |
| UAB Huntsville Regional Medical Campus | Huntsville | Alabama | 35294 | Yogesh Dwivedi, PhD (PRINCIPAL_INVESTIGATOR) Richard C Shelton, MD (PRINCIPAL_INVESTIGATOR) |
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