Cocaine and Pentoxifylline (BED IN 47)

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
William Stoops
Study ID
NCT07086794
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Cocaine Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    The effects of placebo will be determined.
  • Cocaine (IV) — DRUG
    The effects of IV Cocaine will be determined.
  • Pentoxifylline — DRUG
    The effects of pentoxifylline will be determined.

Study Details

This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.

Key Dates

Start date
Nov 10, 2025
Status verified
Jun 2026
Primary completion
Feb 28, 2028
Completion
Feb 28, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo
    Subjects will be treated daily with an oral placebo.
  • Experimental: Pentoxifylline Dose 1
    Subjects will be treated daily with oral pentoxifylline (1200 mg).
  • Experimental: Pentoxifylline Dose 2
    Subjects will be treated daily with oral pentoxifylline (1600 mg).

Primary Outcome Measure

Reinforcing Effects of Cocaine [ Time Frame: 9 times over approximately 1 month inpatient admission ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Psychopharmacology of Addiction LaboratoryLexingtonKentucky40507
William W Stoops, PhD
[email protected]
859-257-5388
William W Stoops, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Lexington, KY

By research site
Psychopharmacology of Addiction Laboratory· Lexington, KY

Related Studies