Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT04721418
Status
Recruiting
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Conditions

  • Cocaine Use Disorder
  • Healthy Controls

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • 11C-UCB-J — RADIATION
    11C-UCB-J PET scan

Study Details

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Key Dates

Start date
Jul 20, 2021
Status verified
Sep 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
80 participants (estimated)

Arms

  • Arm: Cocaine Use Disorder
  • Arm: Healthy Control

Primary Outcome Measure

Between-group (CUD vs. HC) comparisons in ACC. [ Time Frame: CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Connecticut Mental Health CenterNew HavenConnecticut06519
Gustavo Angarita, MD

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Connecticut Mental Health Center· New Haven, CT

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