Imaging CRF X NOP Interactions in CUD

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Rajesh Narendran
Study ID
NCT05008146
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Cocaine Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Baseline [C-11]NOP-1A PET Scan — RADIATION
    Radiotracer
  • Hydrocortisone — DRUG
    Intravenous, 1mg/Kg
  • Post-hydrocortisone [C-11]NOP-1A PET Scan — RADIATION
    Radiotracer

Study Details

This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.

Key Dates

Start date
Dec 31, 2020
Status verified
Jun 2025
Primary completion
Sep 1, 2028
Completion
Sep 1, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET
    \[C-11\]NOP-1A

Primary Outcome Measure

DELTA VT [ Time Frame: Baseline, and 3 hours post-hydrocortisone ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213
Rajesh Narendran
[email protected]
4126475176

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By research site
University of Pittsburgh· Pittsburgh, PA

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