[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Rajesh Narendran
Study ID
NCT05011760
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Cocaine Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Baseline [C-11]NPA PET Scan — RADIATION
    Radiotracer
  • d-amphetamine — DRUG
    Oral, 0.5 mg/Kg
  • Post-amphetamine [C-11]NPA PET Scan — RADIATION
    Radiotracer

Study Details

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

Key Dates

Start date
Jan 31, 2021
Status verified
Jun 2025
Primary completion
Sep 1, 2028
Completion
Sep 1, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET
    \[C-11\]NPA PET Scan

Primary Outcome Measure

DELTA binding potential relative to non displaceable uptake (BPND) [ Time Frame: Baseline, and 2.5 to 3 hours post-amphetamine ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PIttsburghPittsburghPennsylvania15213
Rajesh Narendran
[email protected]
4126475176

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By research site
University of PIttsburgh· Pittsburgh, PA

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