The ROAR Study: Reactive Oxygen Species and Reproduction

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06831019
Status
Recruiting
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Conditions

  • IVF Outcome
  • Ovarian Aging
  • Oxidative Stress

Eligibility Criteria

Sex
ALL
Age
18 Years - 43 Years
Healthy Volunteers
Accepted

Interventions

  • Oxidative stress markers — DIAGNOSTIC_TEST
    We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Study Details

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Key Dates

Start date
Jul 7, 2025
Status verified
Feb 2026
Primary completion
Mar 1, 2027
Completion
Mar 1, 2027

Study Design

Enrollment
1,100 participants (estimated)

Arms

  • Arm: Couples undergoing IVF
    Heterosexual couples undergoing IVF

Primary Outcome Measure

Implantation rate [ Time Frame: From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94158-

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