The Effects of Endotracheal Suctioning on Pain and Serum Markers

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT06692400
Status
Recruiting
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Conditions

  • Adult
  • Biomarkers / Blood
  • COVID
  • Critical Illness
  • Hypoxia
  • Influenza
  • Intensive Care Unit ICU
  • Intubation
  • Mechanical Ventilation
  • Oxidative Stress
  • Pain Measurement
  • Pain, Procedural
  • Pneumonia
  • Sepsis
  • Uric Acid

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • endotracheal tube suctioning — PROCEDURE
    Endotracheal tube suctioning occurs as part of normal care for intubated patients. This procedure will serve as the painful procedure to assess CPOT and biomarkers of hypoxia and oxidative stress.

Study Details

The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress. The main questions this study aims to answer are: Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress. Participants will: Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning. Provide demographic information (like age, gender, and diagnosis) from medical records. This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.

Key Dates

Start date
Jan 30, 2025
Status verified
May 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
110 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Participants who undergo endotracheal tube (ETT) suctioning.
    Participants will receive ETT suctioning as part of routine care.
  • No Intervention: Participants who do not undergo ETT suctioning during the observation period.
    Participants will not receive ETT suctioning during the observation periood.

Primary Outcome Measure

Impact of ETT suctioning on subject pain level [ Time Frame: Change between baseline CPOT score and 30-minutes post suctioning CPOT score. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Loma Linda University Medical Center Troesh Medical CampusLoma LindaCalifornia92354
Loma Linda University Health
[email protected]
877-558-6248
Briana Carr, PhD(c), MEd, BA, BSN, RN (PRINCIPAL_INVESTIGATOR)

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By condition
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By specialty
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By research site
Loma Linda University Medical Center Troesh Medical Campus· Loma Linda, CA

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