Chardonnay Marc and Vascular Response

Part of paid clinical trials in Davis, California.

Sponsor
University of California, Davis
Study ID
NCT05545865
Status
Recruiting
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Conditions

  • Cardiovascular Diseases
  • Oxidative Stress
  • Vascular Dilation

Eligibility Criteria

Sex
MALE
Age
30 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Low Flavanol Cocoa Powder — OTHER
    Measure the response 2 and 6 hours post low flavanol cocoa intake
  • High Flavanol Cocoa Powder — OTHER
    Measure the response 2 and 6 hours post high flavanol cocoa intake
  • Vine to Bar Chocolate - 2 servings — OTHER
    Measure the response 2 and 6 hours post chocolate intake
  • Vine to Bar Chocolate - 1 serving — OTHER
    Measure the response 2 and 6 hours post chocolate intake
  • Vine to Bar Chocolate covered almonds — OTHER
    Measure the response 2 and 6 hours post chocolate covered almond intake

Study Details

This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.

Key Dates

Start date
Sep 1, 2022
Status verified
Feb 2026
Primary completion
Aug 24, 2026
Completion
Aug 24, 2026

Study Design

Enrollment
5 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Placebo Comparator: Low Flavanol Cocoa Powder
    12 g of Low Flavanol Cocoa Powder (30 mg of cocoa flavanols) provided as a beverage mixed in water
  • Experimental: High Flavanol Cocoa Powder
    High Flavanol Cocoa Powder (435 mg of flavanols) will be provided as a beverage mixed in water.
  • Experimental: Two Servings of Vine to Bar Chocolate
    Two servings (60g, 6 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.
  • Experimental: One Serving of Vine to Bar Chocolate
    A single serving (30g, 3 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.
  • Experimental: Vine to Bar Chocolate covered Almonds
    11 pieces (45g) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc, with almonds

Primary Outcome Measure

Framingham Reactive Hyperemia Index (fRHI) [ Time Frame: 6 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Academic Surge, University of California, DavisDavisCalifornia95616
Roberta R Holt, PhD
[email protected]
530-400-5952

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By research site
Academic Surge, University of California, Davis· Davis, CA

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