Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT02480283
Status
Recruiting
Apply to this trial

Conditions

  • Cannabis Smoking
  • Oxidative Stress

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Bronchoscopy — PROCEDURE
    Passage of a thin flexible tube through the mouth, into the windpipe and then into the bronchial tubes so that the study doctor can look into the lungs to perform Bronchoalveolar lavage (BAL), cytologic brushing, and protected specimen brushing.
  • Chest X-ray — RADIATION
    To identify any previously undiagnosed lung disease that will either increase the risk of bronchoscopy or confound results of the study.
  • Venipuncture — PROCEDURE
    To collect blood cells and serum for analyses.
  • Intravenous Catheter — PROCEDURE
    To administer the appropriate medications for the bronchoscopy procedure.

Study Details

This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.

Key Dates

Start date
Nov 11, 2015
Status verified
Oct 2024
Primary completion
Jul 31, 2026
Completion
Jul 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Control
    Subjects aged 18 to 55 who have never used cannabis by self report (validated via urine drug screen), who have never used tobacco/cigarettes and have the capacity to give informed consent.
  • Arm: Cannabis Smokers
    The exposed cohort will have daily or near daily cannabis smoking histories equivalent to a minimum of 20 joint years (number of joints smoked per day multiplied by years of cannabis smoking), will not have a significant tobacco/cigarette smoking history and will be able to provide informed consent.

Primary Outcome Measure

Change in alveolar macrophage phagocytosis related to the use of cannabis [ Time Frame: Baseline and at 18 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado, DenverAuroraColorado80045-

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By research site
University of Colorado, Denver· Aurora, CO

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