Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery

Sponsor
Nanjing First Hospital, Nanjing Medical University
Study ID
NCT05586347
Status
Completed

Conditions

  • Cardiopulmonary Bypass
  • Coronary Artery Bypass Grafting

Eligibility Criteria

Sex
ALL
Age
60 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Nicardipine — DRUG
    Nicardipine 0.2-0.5μg/(kg·min) was infused at the beginning of CPB.
  • normal saline — OTHER
    It has the same capacity as group N。

Study Details

Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery, mainly manifested as mental confusion, anxiety, personality change and memory impairment, which seriously affects the quality of life of patients after surgery.Attention should be paid to the protection of neurological function in patients undergoing cardiac surgery during perioperative period.Nicardipine can selectively act on coronary arteries and cerebral vessels, increase coronary artery and cerebral blood flow, relieve coronary heart disease angina pectoris, protect brain tissue.The cerebral protective effect of nicardipine on cardiovascular surgery under CPB deserves further clinical study.About 15-20% of cardiac output (CO) in healthy adults is allocated to the brain , and cerebral blood flow is supplied by bilateral internal carotid artery (ICA) and vertebral artery (VA), among which ICA provides about 70%-80% of cerebral perfusion flow .However, the location of the internal carotid artery is superficial, the anatomical variation is less, and the ultrasonic Doppler technique is portable and simple to measure. It may be of certain clinical value to use the ultrasonic detection technology to quickly evaluate the cerebral perfusion during the perioperative period, and to early detect and avoid the intraoperative brain function injury.

Key Dates

Start date
Apr 22, 2022
Status verified
Oct 2022
Primary completion
Sep 22, 2022
Completion
Sep 30, 2022

Study Design

Enrollment
64 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: group N
    Nicardipine was infused after initiation of CPB
  • Placebo Comparator: group C
    Give the same volume of normal saline

Primary Outcome Measure

Internal carotid blood flow [ Time Frame: Before induction of anesthesia ]

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