Cardiopulmonary Bypass Induced Red Blood Cell Lysis

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT05189262
Status
Recruiting
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Conditions

  • Cardiac Surgery
  • Cardiopulmonary Bypass
  • Kidney Injury, Acute

Eligibility Criteria

Sex
ALL
Age
18 Years - 88 Years
Healthy Volunteers
Not accepted

Interventions

  • Blood and urine collection — OTHER
    No intervention - Biological specimen collection

Study Details

Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.

Key Dates

Start date
Mar 22, 2022
Status verified
Aug 2025
Primary completion
Dec 31, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Cardiac Sugery Patients Requiring Cardiopulmonary >1hour
    Patients admitted for a complex cardiac surgery, heart valve replacement and/or CABG surgery requiring CPB \>1hour

Primary Outcome Measure

Hemolysis [ Time Frame: Change from baseline at hour 1 during procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Blood Oxygen Transport and HemostasisBaltimoreMaryland21201
Paul W Buehler, PhD
[email protected]
410-706-5171
Tobi Rowden, RN
[email protected]
4107064061

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By research site
Center for Blood Oxygen Transport and Hemostasis· Baltimore, MD

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