Thiamine Intervention and Coronary Artery Bypass Grafting

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT06326996
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Coronary Artery Bypass Grafting
  • Coronary Heart Disease

Eligibility Criteria

Sex
ALL
Age
60 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Thiamine — DRUG
    Participants will be given an infusion of thiamine.
  • Placebo — DRUG
    Participants will be given an infusion of the placebo treatment.

Study Details

The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.

Key Dates

Start date
Oct 10, 2024
Status verified
Jul 2025
Primary completion
Jun 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
52 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Post-CABG patients with Thiamine Treatment Intervention.
    Assess cognition and evaluate blood thiamine, lactate, and inflammatory marker levels in patients receiving thiamine intervention treatment within 5 days (baseline) and one month after CABG.
  • Placebo Comparator: Post-CABG patients without Thiamine Treatment Intervention.
    Assess cognition and evaluate blood thiamine, lactate, and inflammatory marker levels in patients receiving placebo treatment within 5 days (baseline) and one month after CABG.

Primary Outcome Measure

Effects of thiamine treatment intervention on blood lactate levels. [ Time Frame: Baseline and after 1 month after CABG. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLALos AngelesCalifornia90095
Rajesh Kumar, PHD
[email protected]
310-825-1808
Dineth Karunamuni, MS
[email protected]
856-701-5332
Rajesh Kumar, PHD (PRINCIPAL_INVESTIGATOR)

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By research site
UCLA· Los Angeles, CA

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